Results 61 to 70 of about 14,411 (147)

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

A Meta‐Analysis of Antecedents of High‐Performance Work System Use: The Role of Firms’ Strategic and Institutional Environmental Forces

Personnel Psychology, EarlyView.
ABSTRACT Strategic human resource management (HRM) scholars have extensively examined the impact of a high‐performance work system (HPWS) on firm performance outcomes and the conditions that influence this relationship. However, the factors that affect how intensively a firm uses an HPWS remain less understood.
Dishi Hu, In‐Sue Oh, Joo Hun Han, Kaifeng Jiang, Yan Pan, F. Scott Bentley   +5 more
wiley   +1 more source

Perceptions of Hansen's Disease in Northeast Brazil: A Community‐Based Study Integrating Stigma, Empowerment, and Social Distance

Tropical Medicine &International Health, EarlyView.
ABSTRACT Perceptions of Hansen’s disease (HD) can influence the level of stigma, empowerment, and intention to distance oneself from those affected by the disease. Knowledge, attitudes, and beliefs shape these perceptions. This study aims to understand perceptions of HD regarding stigma and empowerment. Method: A cross‐sectional, mixed‐methods research
Jaqueline Caracas Barbosa, Aymée Medeiros da Rocha, Hellen Xavier Oliveira, Nágila Nathaly Lima Ferreira, Adriana da Silva dos Reis, Anderson Fuentes Ferreira, Wim H. van Brakel, Anna T. van ‘t Noordende, Duane Charles Hinders, José Alexandre Menezes da Silva, Carmem Emmanuely Leitão Araújo, Rômulo do Nascimento Rocha, Alberto Novaes Ramos Jr   +12 more
wiley   +1 more source

Not All GLP‐1 Receptor Agonists Are Alike: Real‐World Evidence of Differential Endocrine and Dermatologic Safety

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
ABSTRACT Aims Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are widely used for metabolic disorders, but emerging safety concerns include alopecia and reproductive or endocrine‐related adverse events (AEs). This study investigated the association between specific GLP‐1 RAs and these endocrine‐related AEs using a large‐scale pharmacovigilance ...
Nai Lee, Yun Kim
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Hierarchical Strain‐Modified Medium‐Entropy Carbide Ceramics Exhibit Exceptional Ablation Resistance up to 2400°C

Advanced Science, Volume 13, Issue 19, 2 April 2026.
A novel strategy is developed by doping reduced graphene oxide (rGO) into a (HfZrTi)C medium‐entropy ceramic. This induces a hierarchical strain modification mechanism, synergistically inhibiting crack propagation at the microscale and dissipating stress at the mesoscale.
Junyi Xiao, Pengfei He, Lin Xue, Shujun Hu, Liliang Shao, Chuan Sun, Yunyun Ge, Jiangbo Cheng, Xiubing Liang   +8 more
wiley   +1 more source

Association of Pregabalin vs. Duloxetine with Cardiovascular Events: A Retrospective Cohort Study Among US Veterans With Chronic Musculoskeletal Pain

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1088-1094, April 2026.
Pregabalin and duloxetine are widely prescribed non‐opioid medications for chronic musculoskeletal pain. Pregabalin may increase the risk of heart failure, and duloxetine increases heart rate and blood pressure; however, little is known about their comparative cardiovascular safety.
Sachalee Campbell, Puran Nepal, Laura Daniel, Otis Wilson, Alyson L. Dickson, Jennifer Maizel, Katherine T. Murray, William D. Dupont, Adriana Hung, Wayne A. Ray, C. Michael Stein, Cecilia P. Chung   +11 more
wiley   +1 more source

Deformation and Earthquake Potential on the North America–Caribbean–Cocos Plate Boundary System in Guatemala

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 4, April 2026.
Abstract In Guatemala, the Cocos, North American, and Caribbean plates interact to create a region of high seismic risk. Previous analyses of crustal faults in the country have been overly simplified, creating discrepancies between geologic and geodetic slip rate models.
Jeremy Maurer, Andreas Eckert, Qiaoqi Sun, Jonathan Obrist‐Farner   +3 more
wiley   +1 more source

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single‐Centre Cohort and Systematic Review With Meta‐Analysis

European Journal of Neurology, Volume 33, Issue 4, April 2026.
This study evaluated the efficacy and safety of staged bilateral MR‐guided focused ultrasound (MRgFUS) thalamotomy for medication‐refractory essential tremor (ET) through a prospective cohort and a systematic review with meta‐analysis. Second‐side treatment was associated with sustained tremor reduction, additional functional improvement, and a ...
F. Paio, G. K. Ricciardi, G. Bulgarelli, M. Tagliamonte, E. Mantovani, C. Zucchella, T. Bovi, M. Longhi, Z. Lombardi, P. M. Polloniato, E. Zivelonghi, C. Cavedon, S. Montemezzi, A. Nicolato, F. Sala, B. Petralia, B. Bonetti, M. Tinazzi, S. Tamburin   +18 more
wiley   +1 more source