Results 291 to 300 of about 10,618,209 (336)

Cost-effectiveness decision modelling in social care: exploring the why, the how, and the what next. [PDF]

NIHR Open Res
Huo D, Hinde S, Bojke L, Bauer A, Weatherly H.   +4 more
europepmc   +1 more source

Models of Models of Models of Models of Things

, 2017
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Community participatory approaches in infectious disease dynamic transmission modelling: a scoping review protocol. [PDF]

BMJ Open
Tahmo NB, Idemili C, Noah A, Odhiambo B, Kyalo C, Ligare F, Wanjiku J, Kong JD, Chan AK, Baral S, Walimbwa J, Lazarus L, Puchalski Ritchie LM, Mishra S.   +13 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Subtidal kelp habitat classification at the Isles of Shoals: An integrative Random Forest approach using bathymetry and Landsat imagery. [PDF]

PLoS One
Tyler CN, Lowell K, Parrish CE, Dijkstra JA.   +3 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Model-based methods for hospital infection prevention and control: potential and challenges. [PDF]

BMC Glob Public Health
Bridgen JRE, Jewell C, Lewis JM, Todd S, Semple MG, Feasey N, Read JM.   +6 more
europepmc   +1 more source

Innovative Approach to Understanding Complex Neuroanatomy Through 'Acting-Out', Immersive 3D Modelling. [PDF]

Clin Teach
Kulow C, Sandrock M.
europepmc   +1 more source