Results 91 to 100 of about 6,067,666 (328)

Causal biological network models for reactive astrogliosis: a systems approach to neuroinflammation [PDF]

, 2022
Melinda Barkhuizen, Kasper Renggli, Sylvain Gubian, Manuel C. Peitsch, Carole Mathis, Marja Talikka   +5 more
openalex   +1 more source

Multiscale modeling on biological systems [PDF]

Biochemical and Biophysical Research Communications, 2018
Sulpizi, Marialore, Faller, Roland, Pantano, Sergio   +2 more
openaire   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A validated thermal and biological model for predicting algal productivity in large scale outdoor cultivation systems

, 2021
Jonah M. Greene, David Quiroz, Samuel Compton, Peter J. Lammers, Jason C. Quinn   +4 more
openalex   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Implementation of Agent-Based Models to support Life Cycle Assessment: A review focusing on agriculture and land use

AIMS Agriculture and Food, 2018
Agent-Based Models (ABMs) have been adopted to simulate very different kinds of complex systems, from biological systems to complex coupled human-natural systems.
Antonino Marvuglia, Tomás Navarrete Gutiérrez, Paul Baustert, Enrico Benetto   +3 more
doaj   +1 more source

Building mathematical models of biological systems with modelbase, a Python package for semi-automatic ODE assembly and construction of isotope-specific models [PDF]

, 2018
Oliver Ebenhöh, Marvin van Aalst, Nima P. Saadat, Tim Nies, Anna Matuszyńska   +4 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Assessment of the impacts of biological nitrogen fixation structural uncertainty in CMIP6 earth system models

, 2022
Taraka Davies‐Barnard, Sönke Zaehle, Pierre Friedlingstein   +2 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source