Results 91 to 100 of about 6,631,455 (355)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Modelling the Structure and Dynamics of Biological Pathways.

PLoS Biology, 2016
There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour.
Laura O'Hara, Alessandra Livigni, Thanos Theo, Benjamin Boyer, Tim Angus, Derek Wright, Sz-Hau Chen, Sobia Raza, Mark W Barnett, Paul Digard, Lee B Smith, Tom C Freeman   +11 more
doaj   +1 more source

Requirements for Topology in 3D GIS [PDF]

, 2006
Topology and its various benefits are well understood within the context of 2D Geographical Information Systems. However, requirements in three-dimensional (3D) applications have yet to be defined, with factors such as lack of users' familiarity with the
Ellul, C, Haklay, M
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

Frontiers in Systems Biology
Both machine learning and mechanistic modelling approaches have been used independently with great success in systems biology. Machine learning excels in deriving statistical relationships and quantitative prediction from data, while mechanistic ...
Ben Noordijk, Ben Noordijk, Monica L. Garcia Gomez, Monica L. Garcia Gomez, Kirsten H. W. J. ten Tusscher, Kirsten H. W. J. ten Tusscher, Dick de Ridder, Dick de Ridder, Aalt D. J. van Dijk, Aalt D. J. van Dijk, Robert W. Smith   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models

Nature Communications, 2020
Explicit molecular modelling of biological membrane systems is computationally expensive due to the large number of solvent particles and slow membrane kinetics.
Mohsen Sadeghi, Frank Noé
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Modelling Biological Cr(vi) Reduction in Aquifer Microcosm Column Systems Barrier

Chemical Engineering Transactions, 2011
preview not available - see full-text PDF article.
P. Molokwane, E.M.N. Chirwa
doaj   +1 more source

Measurement set selection of parameter estimation in biological system modelling - a case study of signal transduction pathways [PDF]

, 2012
Parameter estimation is a challenging problem for biological systems modelling since the model is normally of high dimension, the measurement data are sparse and noisy and the cost of experiments high.
Jia, J.F., Yue, Hong
core