Results 101 to 110 of about 7,167,330 (247)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

mlegp: statistical analysis for computer models of biological systems using R [PDF]

, 2008
Garrett M. Dancik, Karin S. Dorman
openalex   +1 more source

Bio-PEPA: A framework for the modelling and analysis of biological systems

Theoretical Computer Science, 2009
Federica Ciocchetta, J. Hillston
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Challenges and opportunities in uncertainty quantification for healthcare and biological systems. [PDF]

Philos Trans A Math Phys Eng Sci
Kimpton LM, Paun LM, Colebank MJ, Volodina V.   +3 more
europepmc   +1 more source

Gene Expression Analysis of Biological Systems Driving an Organotypic Model of Endometrial Carcinogenesis and Chemoprevention [PDF]

, 2008
Doris M. Benbrook, Stan Lightfoot, James Ranger‐Moore, Tongzu Liu, Shylet Chengedza, William L. Berry, Igor Dozmorov   +6 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

UnifiedGreatMod: a new holistic modelling paradigm for studying biological systems on a complete and harmonious scale. [PDF]

Bioinformatics
Aucello R, Pernice S, Tortarolo D, Calogero RA, Herrera-Rincon C, Ronchi G, Geuna S, Cordero F, Lió P, Beccuti M.   +9 more
europepmc   +1 more source

Robustness of mathematical models for biological systems

, 2004
Tianhai Tian
openalex   +2 more sources

The role of predictive modelling in rationally re-engineering biological systems

Nature Reviews Microbiology, 2009
T. Koide, W. L. Pang, N. Baliga
semanticscholar   +1 more source