Results 111 to 120 of about 6,631,455 (355)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Introduction to a Biological Systems Science [PDF]
Biological systems analysis and biodynamic modelling of physiological and biological interrelationships in human body and ...
Bloch, E. +9 more
core +1 more source
Modeling delayed processes in biological systems
Physical Review E, 2016 Delayed processes are ubiquitous in biological systems and are often characterized by delay differential equations (DDEs) and their extension to include stochastic effects. DDEs do not explicitly incorporate intermediate states associated with a delayed process but instead use an estimated average delay time.
Feng, Jingchen +4 more
openaire +5 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Mathematical and computational modelling of post-transcriptional gene relation by micro-RNA [PDF]
, 2009 Mathematical models and computational simulations have proved valuable in many areas of cell biology, including gene regulatory networks. When properly calibrated against experimental data, kinetic models can be used to describe how the concentrations of
Higham, Desmond J., Khanin, Raya
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A hunter-gatherer-farmer population model: Lie symmetries, exact solutions and their interpretation
, 2014 The Lie symmetry classification of the known three-component reaction-diffusion system modelling the spread of an initially localized population of farmers into a region occupied by hunter-gatherers is derived.
Anna Niemcunowicz-Janica (457677) +11 more
core +4 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Computational Modeling of Three-Dimensional Electrodiffusion in Biological Systems: Application to the Node of Ranvier [PDF]
, 2008 Courtney L. Lopreore +6 more
openalex +1 more source
Modelling nematode populations in horticultural systems [PDF]
, 2008 To date, nematode dynamic models have been very simple, driven only by few parameters without accounting for host quality or environment characteristics.
Tixier, Philippe
core