Results 121 to 130 of about 6,631,455 (355)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
AIMS Agriculture and Food, 2018 Agent-Based Models (ABMs) have been adopted to simulate very different kinds of complex systems, from biological systems to complex coupled human-natural systems.
Antonino Marvuglia +3 more
doaj +1 more source
Multiscale models for biological systems
Current Opinion in Colloid & Interface Science, 2010 Life, amazingly rich in diversity of shapes and functions, explores the limits of extreme complexity in nature. In this review we shall discuss in general terms the use of multiscale mathematical and computer models to study the dynamics of biological systems.
M.L. Martins, S.C. Ferreira, M.J. Vilela
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Modular Modeling of Biological Systems
Virtual Biology, 2013 Motivation: Modeling of complex biological systems such as cells, organs or even whole organisms is not a trivial task because of their intricate structure. Although modern computers allow simulation for quite complex models, such models are difficult to support and work with. Modular approach facilitates the creation of complex models by representing
Ilya Kiselev, Fedor Kolpakov
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Integrated ecological modelling for decision support in river management: a lowland river case study (Cauca river in Colombia) [PDF]
, 2010 Several practical concepts and software systems have been recently developed in the issue of environmental decision support. However, the application of ecological modelling approaches that integrate hydrodynamic, physical-chemical, and biological ...
Galvis, Alberto +2 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Overshoot in biological systems modelled by Markov chains: a non‐equilibrium dynamic phenomenon [PDF]
, 2014 Chen Jia, Minping Qian, Daquan Jiang
openalex +1 more source