Results 201 to 210 of about 6,067,666 (328)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Computational Methods for Identification and Modelling of Complex Biological Systems

Complexity, 2019
Alejandro F. Villaverde, Carlo Cosentino, Attila Gábor, Gábor Szederkényi   +3 more
doaj   +1 more source

CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies. [PDF]

Comput Struct Biotechnol J
Weber P, Arnesdotter E, Attar N, Friedrichs S, Seitz C, Chowdhury RR, Koch K, Buerki-Thurnherr T, Brugger B, Wick P, Morikka J, Serra A, Capini L, Greco D, Lacconi V, Marchese AS, Campagnolo L, Exner TE, Brajnik M, Brun É, Lynch I, Zouraris D, Mintis D, Tsoumanis A, Afantitis A, Melagraki G, Minadakis V, Papakyriakopoulou P, Tsiros P, Thépaut E, Sarimveis H, Majó M, Hischier R, Virmani I, Paparella M, Kavaliauskiene S, Sayyari A, Fontaine R, Müller MHB, Lee E, Gerelkhuu Z, Yoon TH, Turan-Sorhun D, Neuhaus W, Serchi T.   +44 more
europepmc   +1 more source

Identifiability methods for biological systems: Determining subsets of parameters through sensitivity analysis, penalty-based optimisation, profile likelihood and LASSO model reduction

Michael Binns, Alessandro Usai, Constantinos Theodoropoulos   +2 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Modelling and predicting the biological effects of nanomaterials

SAR and QSAR in environmental research (Print), 2014
David A. Winkler, F. Burden, Bing Yan, Ralph Weissleder, C. Tassa, Stanley Y. Shaw, V. Epa   +6 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Biophysical modelling as a tool for advancing plant science and engineering. [PDF]

Front Plant Sci
Deb D, Chakrabortty B.
europepmc   +1 more source

Application of modeling calculations in the description of metal ion distribution of bioactive compounds in biological systems

, 2011
Tamás Kiss, Tamás Jakusch, Béla Gyurcsik, Andrea Lakatos, Éva A. Enyedy, Éva Sija   +5 more
openalex   +1 more source

Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio [PDF]

, 2017
Do‐Yeal Ryu, Md Saidur Rahman, Myung‐Geol Pang   +2 more
openalex   +1 more source