Results 211 to 220 of about 7,167,330 (247)

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

In silico modelling of organ-on-a-chip devices: an overview. [PDF]

Front Bioeng Biotechnol
Wang Y, Marucci L, Homer ME.
europepmc   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

FEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Physiology-informed regularisation enables training of universal differential equation systems for biological applications. [PDF]

PLoS Comput Biol
de Rooij M, Erdős B, van Riel NAW, O'Donovan SD.   +3 more
europepmc   +1 more source

Forecasting Range Shifts in Terrestrial Alpine Insects Under Global Warming. [PDF]

Ecol Evol
Meza-Joya FL, Morgan-Richards M, Trewick SA.   +2 more
europepmc   +1 more source

Control of medical digital twins with artificial neural networks. [PDF]

Philos Trans A Math Phys Eng Sci
Böttcher L, Fonseca LL, Laubenbacher RC.   +2 more
europepmc   +1 more source

Generative AI agents are transforming biology research: high resolution functional genome annotation for multiscale understanding of life. [PDF]

EBioMedicine
Harrer S, Rane RV, Speight RE.
europepmc   +1 more source

A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening. [PDF]

Front Bioeng Biotechnol
Botticelli M, Metzcar J, Phillips T, Cox S, Keshavanarayana P, Spill F.   +5 more
europepmc   +1 more source