Results 231 to 240 of about 6,067,666 (328)
From AI-Assisted <i>In Silico</i> Computational Design to Preclinical <i>In Vivo</i> Models: A Multi-Platform Approach to Small Molecule Anti-IBD Drug Discovery. [PDF]
Pharmaceuticals (Basel)Ripa JD +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
A Step-by-Step Computational Protocol for Functional Annotation and Structural Modelling of Insect Chemosensory Proteins. [PDF]
Bio ProtocKalepu R +4 more
europepmc +1 more source
Key role for inhibins in effective T cell activation, migration and Th17 differentiation
FEBS Open Bio, EarlyView.Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco +5 more
wiley +1 more source
Phenomenal interface theory: a model for basal consciousness. [PDF]
Philos Trans R Soc Lond B Biol SciKlein C, Barron AB.
europepmc +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Foundation and challenges in modelling dilute active suspensions. [PDF]
Philos Trans A Math Phys Eng SciFung L, Caldag HO, Bees M.
europepmc +1 more source
A Multiscale Agent-based Model of Morphogenesis in Biological Systems [PDF]
, 2010 Sara Montagna +2 more
openalex
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source