Results 261 to 270 of about 6,067,666 (328)

Numerical Modelling of Keratinocyte Behaviour: A Comprehensive Review of Biochemical and Mechanical Frameworks. [PDF]

Cells
Rashid S, Maiti R, Roy A.
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Parametric FEM-Based Analysis on Adaptive Vein Morphology of Dragonfly Wings Toward Material Efficiency. [PDF]

Biomimetics (Basel)
Zhu G, Teixeira FF, Loh P.
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A Model-Based Reverse System Engineering Methodology for Analyzing Complex Biological Systems With a Case Study in Glycolysis

Gerald L. Fudge, Emily Brown Reeves
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Thermodynamically consistent, reduced models of gene regulatory networks. [PDF]

R Soc Open Sci
Pan M, Gawthrop PJ, Faria M, Johnston ST.   +3 more
europepmc   +1 more source

The archaeology of climate change: a blueprint for integrating environmental and cultural systems. [PDF]

Nat Commun
Burke A, Grove M, Maier A, Wren C, Drapeau M, Poisot T, Moine O, Boisard S, Bruxelles L.   +8 more
europepmc   +1 more source