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Formal Models of Biological Systems
2017Recent biomedical research studies are focused in the mechanisms by which misfolded proteins lead to the generation of oxidative stress in the form of reactive oxygen species (ROS), often implicated in neurodegenerative diseases and aging. Moreover, biological experiments are designed to investigate how proteostasis depends on the balance between the ...
Georgia, Theocharopoulou +2 more
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Modeling of nonlinear biological phenomena modeled by S-systems
Mathematical Biosciences, 2014A central challenge in computational modeling of biological systems is the determination of the model parameters. In such cases, estimating these variables or parameters from other easily obtained measurements can be extremely useful. For example, time-series dynamic genomic data can be used to develop models representing dynamic genetic regulatory ...
Mansouri, Majdi M. +3 more
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Modeling of biological and medical systems: a systemic strategy
Biosystems, 1991A strategy in the frame of General System Theory is proposed for the study of biological systems for medical purposes. Its definition and use requires in each experiment the collaboration between physician and system scientists and hence the definition of a common language, by which the real system under study is described.
P. MUSSIO +7 more
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Artificial systems as models in biological cybernetics
Behavioral and Brain Sciences, 2001From the perspective of biological cybernetics, “real world” robots have no fundamental advantage over computer simulations when used as models for biological behavior. They can even weaken biological relevance. From an engineering point of view, however, robots can benefit from solutions found in biological systems. We emphasize the importance of this
Neumann, T., Huber, S., Bülthoff, H.
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PARTITIONING OF COMPARTMENTAL MODELS IN BIOLOGICAL SYSTEMS
IFAC Proceedings Volumes, 1982Abstract Biological systems are often studied using compartmental models. The complexity of the resulting mathematical problems depends on the choice of a model and the number of compartments used. In many cases the model is restricted to a small number of compartments (2 or 3) so that the associated problems may become easy to solve.
M.S. Kamel +3 more
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Steps of Modeling Complex Biological Systems
Pharmacopsychiatry, 2008A disease like schizophrenia results from the malfunctioning of a complex, multi-faceted biological system. As a consequence, the root causes of such a disease and the trajectories from health toward the disease are very difficult to comprehend with simple cause-and-effect reasoning.
E O, Voit, Z, Qi, G W, Miller
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Minimum realisations and modelling of biological systems
Medical & Biological Engineering, 1975A state variable model in the canonical form of Bucy is constructed from the given impulse response of a finite-dimensional, discrete-time, linear constant dynamical biological (arterial circulatory) system.
R N, Mishra, S S, Koonar
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Modeling of rotating biological contactor systems
Biotechnology and Bioengineering, 1980AbstractAn investigation of the rotating biological contractor (RBC) process variables to determine the efficiency of biological oxygen demand (BOD) removal is presented. Operating parameters including influent BOD content (<355 mg/liter), flow rate, disk surface area, hydraulic loading, disk rotational speed, liquid retention time, stage number ...
Yeun C, Wu, Ed D, Smith, Yung T, Hung
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2020
Modeling of biological systems and ecology is a useful exercise, as it allows one to discover and focus on the important aspects of the life-system dynamics. Population dynamics is a good example. Modeling also helps us understand system optimization. With a long span of time, evolution picks out optimal systems. Models of optimization can be revealing
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Modeling of biological systems and ecology is a useful exercise, as it allows one to discover and focus on the important aspects of the life-system dynamics. Population dynamics is a good example. Modeling also helps us understand system optimization. With a long span of time, evolution picks out optimal systems. Models of optimization can be revealing
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Compartmental Modeling in the Analysis of Biological Systems
2012Compartmental models are composed of sets of interconnected mixing chambers or stirred tanks. Each component of the system is considered to be homogeneous, instantly mixed, with uniform concentration. The state variables are concentrations or molar amounts of chemical species.
James B, Bassingthwaighte +3 more
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