Results 41 to 50 of about 6,067,666 (328)

A Graphical Approach for Hybrid Simulation of 3D Diffusion Bio-Models via Coloured Hybrid Petri Nets

open access: yesModelling and Simulation in Engineering, 2020
Three-dimensional modelling of biological systems is imperative to study the behaviour of dynamic systems that require the analysis of how their components interact in space. However, there are only a few formal tools that offer a convenient modelling of
Amr Ismail   +3 more
doaj   +1 more source

The finding and researching algorithm for potentially oscillating enzymatic systems

open access: yesВавиловский журнал генетики и селекции, 2021
Many processes in living organisms are subject to periodic oscillations at different hierarchical levels of their organization: from molecular-genetic to population and ecological. Oscillatory processes are responsible for cell cycles in both prokaryotes
T. N. Lakhova   +3 more
doaj   +1 more source

Reproducibility in systems biology modelling

open access: yesbioRxiv, 2020
The reproducibility crisis has emerged as an important concern across many fields of science including life science, since many published results failed to reproduce.
Krishna Tiwari   +13 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

piecewiseSEM: Piecewise structural equation modelling in r for ecology, evolution, and systematics [PDF]

open access: yes, 2015
Ecologists and evolutionary biologists rely on an increasingly sophisticated set of statistical tools to describe complex natural systems. One such tool that has gained significant traction in the biological sciences is structural equation models (SEM ...
J. Lefcheck
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Mapping the role of oral cavity physiological factors into the viscoelastic model of denture adhesives for numerical implementation

open access: yesJournal of Applied Biomaterials & Functional Materials, 2023
Physiological parameters of the oral cavity have a profound impact on any restorative solutions designed for edentulous patients including denture adhesives.
Anantha Narayanan Ramakrishnan   +5 more
doaj   +1 more source

Biological applications of knowledge graph embedding models

open access: yesBriefings Bioinform., 2020
Complex biological systems are traditionally modelled as graphs of interconnected biological entities. These graphs, i.e. biological knowledge graphs, are then processed using graph exploratory approaches to perform different types of analytical and ...
Sameh K. Mohamed, A. Nounu, V. Nováček
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

VTR: A Web Tool for Identifying Analogous Contacts on Protein Structures and Their Complexes

open access: yesFrontiers in Bioinformatics, 2021
Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies.
Vitor Pimentel   +7 more
doaj   +1 more source

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