Results 61 to 70 of about 6,631,455 (355)

Reproducibility in systems biology modelling

bioRxiv, 2020
The reproducibility crisis has emerged as an important concern across many fields of science including life science, since many published results failed to reproduce.
Krishna Tiwari, Sarubini Kananathan, Matthew G Roberts, J. Meyer, Mohammad Umer Sharif Shohan, Ashley Xavier, M. Maire, Ahmad Zyoud, Jinghao Men, Szeyi Ng, Tung V. N. Nguyen, Mihai Glont, H. Hermjakob, Rahuman S. Malik-Sheriff   +13 more
semanticscholar   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

piecewiseSEM: Piecewise structural equation modelling in r for ecology, evolution, and systematics [PDF]

, 2015
Ecologists and evolutionary biologists rely on an increasingly sophisticated set of statistical tools to describe complex natural systems. One such tool that has gained significant traction in the biological sciences is structural equation models (SEM ...
J. Lefcheck
semanticscholar   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

Mapping the role of oral cavity physiological factors into the viscoelastic model of denture adhesives for numerical implementation

Journal of Applied Biomaterials & Functional Materials, 2023
Physiological parameters of the oral cavity have a profound impact on any restorative solutions designed for edentulous patients including denture adhesives.
Anantha Narayanan Ramakrishnan, Oliver Röhrle, Christopher Ludtka, Josephine Koehler, Andreas Kiesow, Stefan Schwan   +5 more
doaj   +1 more source

Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching [PDF]

, 2012
A challenging problem in systems biology is parameter inference in mechanistic models of signalling pathways. In the present article, we investigate an approach based on gradient matching and nonparametric Bayesian modelling with Gaussian processes.
Cretella, R., Dondelinger, F., Filippone, M., Husmeier, D., Millar, A., Palmer, T., Rogers, S., Smith, R.   +7 more
core  

Parallel implementation of stochastic simulation for large-scale cellular processes [PDF]

, 2005
Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional ...
Burrage, K., Tian, T.
core   +2 more sources

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

VTR: A Web Tool for Identifying Analogous Contacts on Protein Structures and Their Complexes

Frontiers in Bioinformatics, 2021
Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies.
Vitor Pimentel, Diego Mariano, Letícia Xavier Silva Cantão, Luana Luiza Bastos, Pedro Fischer, Leonardo Henrique Franca de Lima, Alexandre Victor Fassio, Raquel Cardoso de Melo-Minardi   +7 more
doaj   +1 more source

Investigating biocomplexity through the agent-based paradigm. [PDF]

, 2015
Capturing the dynamism that pervades biological systems requires a computational approach that can accommodate both the continuous features of the system environment as well as the flexible and heterogeneous nature of component interactions.
Kaul, H, Ventikos, Y
core