Results 71 to 80 of about 6,067,666 (328)

Modeling and Simulation of Biological Systems with Stochasticity

In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation, 2004
Mathematical modeling is a powerful approach for understanding the complexity of biological systems. Recently, several successful attempts have been made for simulating complex biological processes like metabolic pathways, gene regulatory networks and cell signaling pathways.
Tan Chee, Meng, Sandeep, Somani, Pawan, Dhar   +2 more
openaire   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models

Nature Communications, 2020
Explicit molecular modelling of biological membrane systems is computationally expensive due to the large number of solvent particles and slow membrane kinetics.
Mohsen Sadeghi, Frank Noé
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Modelling Biological Cr(vi) Reduction in Aquifer Microcosm Column Systems Barrier

Chemical Engineering Transactions, 2011
preview not available - see full-text PDF article.
P. Molokwane, E.M.N. Chirwa
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Assessing the combined effects of forest management and climate change on carbon and water fluxes in European beech forests

Forest Ecosystems
The consequences of climate change continue to threaten European forests, particularly for species located at the edges of their latitudinal and altitudinal ranges.
Vincenzo Saponaro, Miquel De Cáceres, Daniela Dalmonech, Ettore D'Andrea, Elia Vangi, Alessio Collalti   +5 more
doaj   +1 more source

Finding the "dark matter" in human and yeast protein network prediction and modelling.

PLoS Computational Biology, 2010
Accurate modelling of biological systems requires a deeper and more complete knowledge about the molecular components and their functional associations than we currently have.
Juan A G Ranea, Ian Morilla, Jon G Lees, Adam J Reid, Corin Yeats, Andrew B Clegg, Francisca Sanchez-Jimenez, Christine Orengo   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source