Biological applications of knowledge graph embedding models
Complex biological systems are traditionally modelled as graphs of interconnected biological entities. These graphs, i.e. biological knowledge graphs, are then processed using graph exploratory approaches to perform different types of analytical and ...
Sameh K. Mohamed, A. Nounu, V. Nováček
semanticscholar +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Development of a Mathematical Model and Numerical Study of the Process of Biological Wastewater Treatment Under Conditions of Uneven Loading of the Treatment System [PDF]
Andrii Safonyk +2 more
openalex +1 more source
Folding and unfolding of a triple-branch DNA molecule with four conformational states [PDF]
Single-molecule experiments provide new insights into biological processes hitherto not accessible by measurements performed on bulk systems. We report on a study of the kinetics of a triple-branch DNA molecule with four conformational states by pulling ...
Anna Alemany +6 more
core +3 more sources
Boolean models of bistable biological systems [PDF]
This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model. Often Boolean models are much simpler to understand than complex differential equations models. The motivation for this work comes from mathematical systems biology.
Hinkelmann, Franziska +1 more
openaire +2 more sources
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Calculation of mathematical models of biological type multiplication and growth
Simulating scheme of calculation of mathematical models of biological object multiplication and growth has been performed with usage of simulating modelling system. Calculation scheme consist of 3 subsystems: simulation of design parameters, simulation
Antanas Lapinskas, Renatas Lapinskas
doaj +3 more sources
Boolean modelling as a logic-based dynamic approach in systems medicine
Molecular mechanisms of health and disease are often represented as systems biology diagrams, and the coverage of such representation constantly increases.
Ahmed Abdelmonem Hemedan +3 more
doaj +1 more source
Degeneracy: a link between evolvability, robustness and complexity in biological systems [PDF]
A full accounting of biological robustness remains elusive; both in terms of the mechanisms by which robustness is achieved and the forces that have caused robustness to grow over evolutionary time.
J. Whitacre, A. Bender
semanticscholar +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source

