Results 81 to 90 of about 6,631,455 (355)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Contrasting patterns of water use efficiency and annual radial growth among European beech forests along the Italian peninsula

Scientific Reports
Tree mortality and forest dieback episodes are increasing due to drought and heat stress. Nevertheless, a comprehensive understanding of mechanisms enabling trees to withstand and survive droughts remains lacking.
Paulina F. Puchi, Daniela Dalmonech, Elia Vangi, Giovanna Battipaglia, Roberto Tognetti, Alessio Collalti   +5 more
doaj   +1 more source

WIBL: Workbench for Integrative Biological Learning

Journal of Integrative Bioinformatics, 2011
The construction of integrated datasets from potentially hundreds of sources with bespoke formats, and their subsequent visualization and analysis, is a recurring challenge in systems biology.
Lesk Victor, Taubert Jan, Rawlings Chris, Dunbar Stuart, Muggleton Stephen   +4 more
doaj   +1 more source

Modelling Cell Cycle using Different Levels of Representation

, 2009
Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources.
Antonio Cerone, Gabriel Ciobanu, Rafael V. Carvalho, Thomas Anung Basuki   +3 more
core   +2 more sources

Robust and efficient parameter estimation in dynamic models of biological systems

BMC Systems Biology, 2015
BackgroundDynamic modelling provides a systematic framework to understand function in biological systems. Parameter estimation in nonlinear dynamic models remains a very challenging inverse problem due to its nonconvexity and ill-conditioning. Associated
A. Gábor, J. Banga
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Integrating modelling of biodiversity composition and ecosystem function [PDF]

, 2015
There is increasing reliance on ecological models to improve our understanding of how ecological systems work, to project likely outcomes under alternative global change scenarios and to help develop robust management strategies.
Adler, Agrawal, Anderson, Arkema, Aumann, Botkin, Boulangeat, Breckling, Brose, Brown, Brown, Buisson, Cabral, Cardinale, Cardinale, Carpenter, Cockshott, Coops, Currie, D'Amen, Diniz-Filho, Dubuis, Duffy, Dunstan, Díaz, Elith, Evans, Evans, Evans, Ferrier, Ferrier, Follows, Fontes, Frank, Fraser, Fulton, Fulton, Fulton, Gaston, Gaston, Gaston, Gaston, Goudriaan, Grantham, Grimm, Gross, Guisan, Harfoot, Harfoot, Harte, Hendriks, Hendriks, Hickler, Hooper, Hooper, Horning, Hubbell, Isbell, Jenkins, Kearney, Keith, Kissling, Kleidon, Laughlin, Levins, Liedloff, Lischke, Loeuille, Lomolino, Loreau, Loreau, Lucht, MacArthur, Maury, Miles, Mokany, Mokany, Mokany, Mokany, Mokany, Mora, Naeem, Noss, Parton, Peck, Peck, Pellissier, Peng, Pillai, Pollock, Potter, Purves, Rangel, Runge, Schindler, Schramski, Schulze, Shea, Shipley, Shokralla, Sitch, Smith, Sommer, Supp, Thomson, Thuiller, Tilman, Trainor, Van Nes, VanDerWal, White, Wiegand, Wild, Wintle, Worm, Zellmer, Zurell   +116 more
core   +1 more source