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Biologic models of neurodegenerative disorders
2008Publisher Summary In human neurodegenerative disorders, genetic mutations that are identified in familiar forms of disease have served as a starting point for recapitulating the underlying pathological processes in biologic models. The central rationale supporting the development of biologic models is that they enable researchers to apply powerful ...
Jason L, Eriksen +2 more
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Formal Models of Biological Systems
2017Recent biomedical research studies are focused in the mechanisms by which misfolded proteins lead to the generation of oxidative stress in the form of reactive oxygen species (ROS), often implicated in neurodegenerative diseases and aging. Moreover, biological experiments are designed to investigate how proteostasis depends on the balance between the ...
Georgia, Theocharopoulou +2 more
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The biological foundation of the Gompertz model
International Journal of Bio-Medical Computing, 1987The paper examines the biological reasoning of the Gompertz model for tumor growth: the increase and loss rates of the tumor volume are both proportional to the volume itself. The statement is proved mathematically. The theoretical foundation is therefore established, this ensures the application of the Gompertz model as an effective aid for the ...
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Modeling of biological tree structures
Bulletin of Mathematical Biology, 1979Biological tree-like structures, such as mammalian tracheobronchial airways, are complicated branching systems. One problem in modeling such systems is the reassignment of the number of segments at a given generation in the model being constructed. A hypothesis is proposed which has successfully been used in modeling mammalian lung airways.
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Network model as a biological pacemaker
Journal of Theoretical Biology, 1970Abstract A network model with a reverberatory mechanism is proposed for biological pacemakers. The reverberatory circuit is to be a bundle of interacting loops instead of a single loop. Random amplitude variations are accounted for by a “beat” phenomenon between two bundles. Moreover, a mechanism is proposed for the transformation of a quasi-periodic
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Modelling the biological membrane
Biochemical Society Transactions, 1987T D, Madden, M J, Hope, P R, Cullis
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