Results 111 to 120 of about 23,798,154 (337)

ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]

, 2015
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore, Mueller, T., Richards, Am   +2 more
core   +1 more source

Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors

European Heart Journal, 2017
Aims The aim of this study is to develop models to aid the decision to prolong dual antiplatelet therapy (DAPT) that requires balancing an individual patient’s potential benefits and harms.
L. Pasea, Sheng-Chia Chung, M. Pujades-Rodriguez, A. Moayyeri, Spiros C. Denaxas, K. Fox, L. Wallentin, S. Pocock, A. Timmis, A. Banerjee, R. Patel, H. Hemingway   +11 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Cardiovascular function and ballistocardiogram: a relationship interpreted via mathematical modeling [PDF]

, 2019
Objective: to develop quantitative methods for the clinical interpretation of the ballistocardiogram (BCG). Methods: a closed-loop mathematical model of the cardiovascular system is proposed to theoretically simulate the mechanisms generating the BCG ...
Despins, Laurel, Enayati, Moein, Guidoboni, Giovanna, Huxley, Virginia H., Keller, James, Popescu, Mihail, Sacco, Riccardo, Sala, Lorenzo, Skubic, Marjorie, Szopos, Marcela   +9 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]

, 2018
BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina, Graham, Delyth, Milligan, Graeme, Nicklin, Stuart A.   +3 more
core   +1 more source

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. [PDF]

, 2020
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations.
Anza-Ramirez, Cecilia, Corante, Noemi, DeYoung, Pamela N, Djokic, Matea A, Gaio, Eduardo, Gilbertson, Dillon, Heinrich, Erica C, Macarlupu, Jose L, Malhotra, Atul, Orr, Jeremy E, Powell, Frank L, Simonson, Tatum S, Villafuerte, Francisco C, Vizcardo-Galindo, Gustavo   +13 more
core   +1 more source

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk: Insights From the FOURIER Trial

Circulation, 2019
Background: Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration.
M. O’Donoghue, S. Fazio, R. Giugliano, Erik S. G. Stroes, Estella Kanevsky, I. Gouni-Berthold, K. Im, Armando Lira Pineda, S. Wasserman, R. Češka, M. Ezhov, J. Jukema, Henrik K. Jensen, S. Lale Tokgözoğlu, F. Mach, K. Huber, P. S. Sever, A. Keech, T. Pedersen, M. Sabatine   +19 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Advances in semantic representation for multiscale biosimulation: a case study in merging models [PDF]

, 2009
As a case-study of biosimulation model integration, we describe our experiences applying the SemSim methodology to integrate independently-developed, multiscale models of cardiac circulation. In particular, we have integrated the CircAdapt model (written
Arts, Theo, Cook, Daniel L, Gennari, John H, Neal, Maxwell L   +3 more
core   +1 more source