Results 171 to 180 of about 25,447,146 (290)

CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies. [PDF]

Comput Struct Biotechnol J
Weber P, Arnesdotter E, Attar N, Friedrichs S, Seitz C, Chowdhury RR, Koch K, Buerki-Thurnherr T, Brugger B, Wick P, Morikka J, Serra A, Capini L, Greco D, Lacconi V, Marchese AS, Campagnolo L, Exner TE, Brajnik M, Brun É, Lynch I, Zouraris D, Mintis D, Tsoumanis A, Afantitis A, Melagraki G, Minadakis V, Papakyriakopoulou P, Tsiros P, Thépaut E, Sarimveis H, Majó M, Hischier R, Virmani I, Paparella M, Kavaliauskiene S, Sayyari A, Fontaine R, Müller MHB, Lee E, Gerelkhuu Z, Yoon TH, Turan-Sorhun D, Neuhaus W, Serchi T.   +44 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years.

Cold Spring Harbor Protocols, 2015
C. Kemp
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Drug toxicity prediction based on genotype-phenotype differences between preclinical models and humans. [PDF]

EBioMedicine
Park M, Song W, Ahn H, Kim S.
europepmc   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation. [PDF]

Curr Environ Health Rep
Luechtefeld T, Hartung T.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Beyond animal testing: An integrated framework for modern chemical hazard identification and risk assessment. [PDF]

Environ Sci Ecotechnol
Fan T, Yan Z, Feng C, Wu F.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source