Results 151 to 160 of about 1,516,599 (318)

Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma

BMC Medicine
Background Cholangiocarcinoma (CCA) remains a highly lethal malignancy with a dismal prognosis, primarily driven by therapeutic resistance. A dominant resistance mechanism involves overexpression of anti-apoptotic BCL-2 proteins (BCL-XL, BCL-2, MCL-1 ...
Qinghua Zeng, Yan Zhang, Yiwen Yang, Xin Liu, Xin Dong, Yongzhang Pan, Li Hu, Ao Zhang, Jian Yang, Qiuni Luo, Xiang Lai, Guoping Zhu, Xuan Zhang, Yonghan He   +13 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia : GENFI results [PDF]

: INTRODUCTION Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD).
Petr, Jan, Butler, Chris, Masellis, Mario, Rogaeva, Ekaterina, Graff, Caroline, Jiskoot, Lize C., Bocchetta, Martina, Bouzigues, Arabella, Seelaar, Harro, Santana, Isabel, Tartaglia, Maria Carmela, Russell, Lucy L., Laforce, Robert, Synofzik, Matthis, Mitchell, Sara B., Galimberti, Daniela, Freedman, Morris, Genetic Frontotemporal Dementia Initiative (GENFI), Moreno, Fermin, Ducharme, Simon, Sorbi, Sandro, Finger, Elizabeth, Gerhard, Alex, Black, Sandra E., Luciw, Nicholas, Levin, Johannes, van Swieten, John C, Mirza, Saira S., Rowe, James B., de Mendon\ue7a, Alexandre, Otto, Markus, Cash, David, Pasternak, Maurice, Tiraboschi, Pietro, MacIntosh, Bradley J., Sanchez-Valle, Raquel, Tang-Wai, David, Rohrer, Jonathan D., Bruffaerts, Rose, Borroni, Barbara, Strafella, Antonio P., Thomas, David, Mutsaerts, Henri J.M.M., Vandenberghe, Rik   +43 more
core  

YTHDF1/RNF7/p27 axis promotes prostate cancer progression

Cell Death and Disease
Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling ...
Yulin Shi, Baiyang Liu, Yong Zhang, Sen Zhao, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng, Cuiping Yang, Yongbin Chen   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets

MedComm
Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses.
Ayesha Nisar, Sawar Khan, Wen Li, Li Hu, Priyadarshani Nadeeshika Samarawickrama, Naheemat Modupeola Gold, Meiting Zi, Sardar Azhar Mehmood, Jiarong Miao, Yonghan He   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Forecasting Regional Employment in Germany by Means of Neural Networks and Genetic Algorithms [PDF]

The aim of this paper is to develop and apply Neural Network (NN) models in order to forecast regional employment patterns in Germany. NNs are statistical tools based on learning algorithms with a distribution over a large amount of quantitative data ...
Simonetta Longhi, Aura Reggiani, Peter Nijkamp, Roberto Patuelli   +3 more
core  

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

Genome Biology
Background Understanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recombination remains poorly understood
Shao-Jie Zhang, Jilong Ma, Meritxell Riera, Søren Besenbacher, Julia E. Niskanen, Noora Salokorpi, Sruthi Hundi, Marjo K. Hytönen, Tong Zhou, Gui-Mei Li, Elaine A. Ostrander, Mikkel Heide Schierup, Hannes Lohi, Guo-Dong Wang   +13 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source