Results 191 to 200 of about 27,951,681 (317)

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.

Molecular biology and evolution, 2007
K. Tamura, J. Dudley, M. Nei, Sudhir Kumar   +3 more
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Comparative Study of Molecular Descriptors and AI-Based Embeddings for Toxicity Prediction. [PDF]

Chem Res Toxicol
Gray M, Wu L.
europepmc   +1 more source

Partitionfinder: combined selection of partitioning schemes and substitution models for phylogenetic analyses.

Molecular biology and evolution, 2012
R. Lanfear, B. Calcott, S. Ho, Stéphane Guindon   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Deep Generative AI for Multi-Target Therapeutic Design: Toward Self-Improving Drug Discovery Framework. [PDF]

Int J Mol Sci
Kang SI, Shin JH, Wu BM, Choi HS.
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Visualizing mechanistic models by integrating site-specific molecular details into reaction networks. [PDF]

Front Mol Biosci
Vasilescu D, Schaff JC, Moraru II, Blinov ML.   +3 more
europepmc   +1 more source

Deep Generative Models for Molecular Science

Molecular Informatics, 2018
P. B. Jørgensen, Mikkel N. Schmidt, O. Winther   +2 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source