Results 251 to 260 of about 3,022,054 (299)

QSAR Models for Sweetness: Can They Shape the Future of Nutritional Safety? [PDF]

Foods
Toropova AP, Toropov AA, Raŝka I, Raŝkova M, Achary PGR.   +4 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Facilitating Heterogeneous Effect Estimation via Statistically Efficient Categorical Modifiers. [PDF]

J Am Stat Assoc
Kowal DR.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Optimization of a fresh fecal intraperitoneal injection sepsis model and its divergent dynamics from cecal ligation and puncture in mice. [PDF]

Lab Anim Res
Zhao L, Wu Z, Zhong Z, Lu X, Zhang R, Luo L, Lu Y, Yue X.   +7 more
europepmc   +1 more source

Accurate prediction of activity cliff compounds based on bioactivity profiles depends on assay nearest neighbor relationships. [PDF]

J Cheminform
Abe R, Miyao T, Bajorath J.
europepmc   +1 more source

A comparative analysis of the performance of leading large language models on the endodontics section of the dentistry specialization exam in Türkiye. [PDF]

PLoS One
Başkan B, Başkan HK, Koç N.
europepmc   +1 more source

TIMEL: Deep learning-statistical integration reveals spatial stromal and immune signatures of aggressive colon cancer. [PDF]

J Pathol Inform
Le MK, Liu X, Vaickus L, Yao K, Levy J.
europepmc   +1 more source