Results 121 to 130 of about 23,153,291 (313)

Macroscopic traffic models from microscopic car-following models

, 2001
We present a method to derive macroscopic fluid-dynamic models from microscopic car-following models via a coarse-graining procedure. The method is first demonstrated for the optimal velocity model.
B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, D. C. Gazis, D. Chowdhury, D. E. Wolf, D. Helbing, D. Helbing, D. Helbing, D. Kim, E. Tomer, H. K. Lee, H. Y. Lee, H. Y. Lee, H. Y. Lee, H.-W. Lee, I. Prigogine, I. Treiterer, K. Nagel, K. Nagel, L. Neubert, M. Bando, M. Hermann, M. Koshi, M. Schreckenberg, M. Treiber, M. Treiber, N. Mitarai, N. Mitarai, O. Biham, P. Nelson, R. Herman, S.-I. Tadaki, T. Nagatani, T.S. Komatsu   +36 more
core   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Globalisation and the reform of European social models [PDF]

This Policy Contribution by André Sapir was presented to the ECOFIN informal meeting in Manchester. See also the Policy Brief based on this paper.
André Sapir
core   +1 more source

Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum

Veterinary Sciences
Caffeic acid phenethyl ester (CAPE) is one of the main active components of the natural medicine propolis, which has antioxidant, anti-tumor, and immunomodulatory activities. This study aimed to analyze the effects and underlying mechanisms of CAPE added
Chu-Man Huang, Hui-Mei Huang, Ying-Hua Li, Xing-Wei Liang, Nam-Hyung Kim, Yong-Nan Xu   +5 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Automated Statistical Model Discovery with Language Models [PDF]

arXiv
Statistical model discovery is a challenging search over a vast space of models subject to domain-specific constraints. Efficiently searching over this space requires expertise in modeling and the problem domain. Motivated by the domain knowledge and programming capabilities of large language models (LMs), we introduce a method for language model ...
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Interacting damage models mapped onto Ising and percolation models

, 2004
We introduce a class of damage models on regular lattices with isotropic interactions, as e.g. quasistatic fiber bundles. The system starts intact with a surface-energy threshold required to break any cell sampled from an uncorrelated quenched-disorder ...
A. A. Griffith, C. E. Shannon, C. J. Thompson, D. Stauffer, F. T. Peirce, H. E. Daniels, J. O. H. Bakke, K. Huang, L. D. Landau, Renaud Toussaint, Steven R. Pride   +10 more
core   +4 more sources

Exploring Actions, Interactions and Challenges in Software Modelling Tasks: An Empirical Investigation with Students [PDF]

arXiv
Background: Software modelling is a creative yet challenging task. Modellers often find themselves lost in the process, from understanding the modelling problem to solving it with proper modelling strategies and modelling tools. Students learning modelling often get overwhelmed with the notations and tools.
arxiv  

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source