Semantic design: Programming functional genes from genomic context. [PDF]
Huang Y, Lin P.
europepmc +1 more source
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen +6 more
wiley +1 more source
Lamination-Controlled Lithofacies Differentiation and Shale Oil Enrichment: A Case Study of the Qingshankou Formation, Songliao Basin. [PDF]
Yao Q +9 more
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We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham +11 more
wiley +1 more source
Changes in thalamic metabolites correlate with severity of spinal cord injury based on diffusion tensor imaging in patients with cervical spondylotic myelopathy. [PDF]
Mu X +5 more
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Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López +5 more
wiley +1 more source
Dynamic heterogeneity and hidden fluidity in dense epithelial tissues. [PDF]
Shen Y, Xi W, Mège RM, Kob W, Ladoux B.
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The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan +13 more
wiley +1 more source
Observer effect modulates classification in a quantum epistemic framework. [PDF]
Hoorn JF, Ho JKW.
europepmc +1 more source
Network Disconnection Syndrome in Unruptured Brain Arteriovenous Malformations: A Multimodal Connectome Study. [PDF]
Dong X +11 more
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