Results 231 to 240 of about 2,706,843 (321)

α‐Amination of 1,3‐Dicarbonyl Compounds and Analogous Reactive Enolate‐Precursors Using Ammonia Under Oxidative Conditions

open access: yesAngewandte Chemie International Edition, Accepted Article.
We herein introduce a method for the direct a‐amination of different carbonyl compounds by employing aqueous ammonia as the N‐source. Upon using NH3 in combination with hypochlorites as simple oxidants under phase‐transfer catalytic conditions it is possible to carry out the direct a‐amination of reactive enolate‐precursors such as cyclic b‐ketoesters,
Christopher Mairhofer   +6 more
wiley   +1 more source

Continuous Flow Synthesis of Nitrofuran Pharmaceuticals using Acetyl Nitrate

open access: yesAngewandte Chemie International Edition, Accepted Article.
Nitrofurfural is a key building block for the synthesis of antimicrobial nitrofurans as active pharmaceutical ingredients. Its synthesis involves the nitration of furfural, a substrate derived from biobased resources. However, furfural has a delicate heteroaromatic backbone.
Hubert Hellwig   +8 more
wiley   +1 more source

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