Results 101 to 110 of about 21,705 (266)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The Role of Work Motivation in Moderating the Influence of Competence, Workload, and Organizational Support on the Performance of Intelligence Employees at the Lima Puluh Kota Police Station

AMAR (Andalas Management Review)
This study examines the role of work motivation as a moderator of the effects of competence, workload, and organizational support on the performance of Intelligence and Security personnel (Intelkam) at the Lima Puluh Kota Police Resort.
Deby Kurnia Putra, Delfia Tanjung Sari
doaj  

A Meta-Analysis of Determinants of Success and Failure of Economic Sanctions

Econometrics
Political scientists and economists often assert that they understand how economic sanctions function as a foreign policy tool and claim to have backed their theories with compelling statistical evidence.
Binyam Afewerk Demena, Peter A. G. van Bergeijk   +1 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Institutional quality and life satisfaction in Latin America: insights from a within-between approach

Development Studies Research
This paper explores how institutional quality relates to subjective well-being in Latin America, a region often described by a ‘well-being paradox’: relatively high life satisfaction despite modest incomes and persistent governance problems.
Maria Chaykina, Lucía Gómez-Balcácer, Nicola Pontarollo, Joselin Segovia   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The Impact of EPU on the Relation Between International Oil Price Shocks and the Chinese Stock Market: Industry and Transnational Perspectives

International Journal of Financial Studies
In this study, we employ the panel smooth transition (PSTR) model to establish a nonlinear framework for examining the relationship between international oil prices and stock returns in China.
Xin Huang, Yang Gao
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Teachers' judgment accuracy: A replication check by psychometric meta-analysis.

PLoS ONE
Teachers' judgment accuracy is a core competency in their daily business. Due to its importance, several meta-analyses have estimated how accurately teachers judge students' academic achievements by measuring teachers' judgment accuracy (i.e., the ...
Esther Kaufmann
doaj   +1 more source