Results 161 to 170 of about 3,027,754 (307)

Message from the Spiritual Advisor: Modern Age Challenges Physicians [PDF]

, 1986
Lorenzetti, Dino J.
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Value of autopsy in the modern age: Discrepancy between clinical and autopsy diagnoses. [PDF]

World J Exp Med
Salzillo C, Basile R, Cazzato G, Ingravallo G, Marzullo A.   +4 more
europepmc   +1 more source

Bringing family medicine into the modern age. [PDF]

CMAJ, 2019
Bouchard B.
europepmc   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Left Ventricular Reverse Remodeling after Successful Living Donor Kidney Transplantation: The Visualizing the Pathophysiology of Kidney Transplantation in Modern Age Study. [PDF]

Kidney360
Hidaka S, Kobayashi S, Tanabe K, VINTAGE Investigators.   +3 more
europepmc   +1 more source

Rodent outbreaks: an age-old issue with a modern appraisal [PDF]

, 2010
Belmain, S.R., Brown, P.R., Singleton, G.R.   +2 more
core  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Frequencies of enamel hypomineralisation in permanent and primary molars in a medieval and early-modern-age population (7th - 17th c.) in Sains-en-Gohelle (Pas de Calais, France). [PDF]

Sci Rep
Estivals J, Couture C, Rouas P, Manton DJ, Garot E.   +4 more
europepmc   +1 more source