Results 51 to 60 of about 55,758 (306)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
“Here we are … somewhere else, some other time”: The Referencing of Modernism in the Reception of Two British Metamodern Novels [PDF]
Acta PhilologicaThis article investigates the use of references to (High) Modernism in the reception of two contemporary British novels that have been categorised as metamodern by scholars: Will Self’s Umbrella (2012) and Zadie Smith’s NW (2012).
Dennis Kersten, Usha Wilbers
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Historiographical aspects of the Study of Catholic Modernism in Italy
Российский журнал истории ЦерквиThe article highlights the main directions of modern Italian historiography in the study of the crisis of Catholic modernism. Modernism was not included in the sphere of interests of Italian scientists until the pontificate of John XXIII (1958–1963) due ...
Marina N. Bakhmatova
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Story of Post-Modernism: Five Decades of the Ironic, Iconic and Critical in Architecture
Journal of Architectural/Planning Research and Studies (JARS), 2014 คำวา “โพสตโมเดรน (Postmodernism)” สำหรบ นกวชาการทางสถาปตยกรรมและสถาปนกอกจำนวนมาก นน เปนคำทอยภายใตกรอบแหงความหมายเฉพาะ และ ผกรอยตดกบรปธรรมของงานออกแบบ และหวงกาลอน เจาะจงคอทศวรรษท 1960-1980 ในวงลอแหงเวลาทหมน เปลยนไปเรอย ๆ สถาปนกและนกออกแบบจำนวนมากเหน ...
Santirak Prasertsuk
semanticscholar +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source