Results 41 to 50 of about 186,815 (190)
Habermas and the Other Side of Modernity
Ethiopian Journal of the Social Sciences and Humanities, 2012 This essay tries to critique the concept of modernity through a discussion of Jürgen Habermas’ communicative rationality and modernity as an unfinished project.
Fasil Merawi
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Reimagining Mediterranean Spaces: Libya and the Italo-Turkish War, 1911-1912 [PDF]
Diacronie. Studi di Storia Contemporanea, 2015 The Italo-Turkish War, a struggle over the territory that the Italian occupiers later re-christened as Libya, became a heated ideological battleground for the emerging nationalisms of the Mediterranean.
Jonathan McCollum
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Water Alternatives, 2019 Jeff Malpasʼ concept of place as a bounded, open, and emergent structure is used in this article to understand the reasons for the differences in villagersʼ responses to 'artificial glaciers', or 'Ice stupas', built in two different places in the ...
Arjun Sharma
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Geography of modernity and geography of post modernity
GEOUSP: Espaço e Tempo, 1999 This text discusses different epistemological approaches that Geography assumes in these two civilizatory moments. It starts from the paradigms imposed by positivist philosophy and the theoretic analyse's forms Geography was required (to be universal and
Amalia Inés Geraiges de Lemos
doaj +1 more source