Results 131 to 140 of about 989,684 (264)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Microphysical Characteristics of Melting Layers in North China Revealed by Aircraft and Radar
Remote SensingThe microphysical processes within the melting layer (ML) of stratiform clouds have been understudied, particularly regarding their intricate properties and behaviors.
Xiangfeng Hu +8 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Scavenging effect analysis of precipitation on PM2.5 and PM10 in Sichuan Basin
暴雨灾害The Sichuan Basin is one of the most severely air-polluted regions in China. To study the scavenging effect of precipitation on PM2.5 and PM10 in Sichuan Basin, the PM2.5 and PM10 mass concentration data from 90 environmental monitoring stations and ...
Sasa ZHENG +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Duplex Surface Modification of M2 High-Speed Steel
In this investigation, a duplex surface modification of M2 high-speed steel (HSS) was demonstrated, including electron beam treatment (EBT) followed by a tungsten nitride (WN) coating deposition.
Georgi Kotlarski +5 more
core +1 more source
Precipitation, cloud changes and impacts project (PreCIIP) results from the 1989 exploratory cloud seeding experiment in Illinois: Annual report [PDF]
, 1992 Made available in DSpace on 2016-11-14T22:31:48Z (GMT). No. of bitstreams: 2 ISWSCR-559.pdf: 3288078 bytes, checksum: 8d01071b6525e5fda565b925d7976f39 (MD5) license.txt: 3973 bytes, checksum: 6c1c5beee39794d995a5ff442f5bd9ab (MD5) Previous issue date ...
Changnon, Stanley Alcide
core +1 more source