Results 51 to 60 of about 15,592 (274)

A Machine Learning Prediction Model of Respiratory Failure Within 48 Hours of Patient Admission for COVID-19: Model Development and Validation

Journal of Medical Internet Research, 2021
BackgroundPredicting early respiratory failure due to COVID-19 can help triage patients to higher levels of care, allocate scarce resources, and reduce morbidity and mortality by appropriately monitoring and treating the patients at greatest risk for ...
Bolourani, Siavash, Brenner, Max, Wang, Ping, McGinn, Thomas, Hirsch, Jamie S, Barnaby, Douglas, Zanos, Theodoros P   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Incidence of cardiac arrests and unexpected deaths in surgical patients before and after implementation of a rapid response system [PDF]

, 2012
BACKGROUND: Rapid response systems (RRSs) are considered an important tool for improving patient safety. We studied the effect of an RRS on the incidence of cardiac arrests and unexpected deaths.METHODS: Retrospective before- after study in a university ...
Schoonhoven, Lisette, Van der Hoeven, J.G., Fikkers, B.G., Simmes, F., Mintjes, J.A.   +4 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

The development, validation and testing of a vital signs monitoring tool for early identification of deterioration in adult surgical patients [PDF]

, 2011
Patients often exhibit premonitory abnormalities in vital signs before an adverse clinical outcome. Patient survival may depend on the decisions of nurses to call for assistance.
Kyriacos, Una
core  

Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis.

PLoS ONE, 2019
BACKGROUND:Although scoring and machine learning methods have been developed to predict patient deterioration, bedside assessment by nurses should not be overlooked.
Hyung-Jun Kim, Hyun-Ju Min, Dong-Seon Lee, Yun-Young Choi, Miae Yoon, Da-Yun Lee, In-Ae Song, Jun Yeun Cho, Jong Sun Park, Young-Jae Cho, You-Hwan Jo, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Yeon Joo Lee   +14 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Application of the Modified Early Warning Score by Nurse in Hospitals

, 2022
Objetivo: identificar como o Modified Early Warning Score (MEWS) tem sido aplicado na prática clínica hospitalar pelo enfermeiro. Método:  trata-se de uma revisão integrativa da literatura; para a elaboração da questão norteadora utilizou-se a estratégia PICO conforme recomendação do Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA): O ...
Maximiano, Luzia Cibele de Souza, Araújo, Maria Eduarda da Silva, Vieira, Alcivan Nunes, Dantas, Luana Adrielle Leal, Oliveira, Lucidio Clebeson de, Rodrigues, Helder Barbosa   +5 more
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source