Results 81 to 90 of about 59,822 (239)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Optimization by signal flow graph method
, 1971 Five related objectives were realized in this research; 1. A modified linear programming technique was developed. The procedure follows the simplex algorithm, but signal flow graph (SFG) methods rather than matrix manipulations are used. 2.
Tonomura, Takashi
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White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Lagrangian Relaxation / Dual Approaches For Solving Large-Scale Linear Programming Problems
, 1997 This research effort focuses on large-scale linear programming problems that arise in the context of solving various problems such as discrete linear or polynomial, and continuous nonlinear, nonconvex programming problems, using linearization and branch ...
Madabushi, Ananth R.
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk +16 more
wiley +1 more source
Frequency optimization of laminated composite skew sandwich plates
, 2013 101-107This paper deals with frequency optimization of skew sandwich plate with laminated composite faces. The design objective is the maximization of the fundamental frequency and the design variable is the fiber orientations of the top and buttom ...
Uzman, Ümit, Topal, Umut
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A Finite Improvement Algorithm for the Linear Complementarity Problem [PDF]
, 1983 This research is concerned with the development of a computationally efficient improvement algorithm for the linear complementarity problem (LCP). Our approach to finding a solution to the LCP is to solve the equivalent constrained optimization problem ...
Paparrizos, Konstantinos
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Thermal buckling load optimization of laminated skew plates
, 2009 In this study thermal buckling load optimization of laminated skew plates subjected to uniformly distributed temperature load is investigated. All of the laminates considered are assumed to have fully clamped boundary conditions, though the general ...
Topal, U., Uzman, Ue.
core +1 more source