Results 91 to 100 of about 3,110 (254)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

The chiral quark condensate and pion decay constant in nuclear matter at next-to-leading order [PDF]

, 2010
Making use of the recently developed chiral power counting for the physics of nuclear matter (Oller et al 2010 J. Phys. G: Nucl. Part. Phys. 37 015106, Lacour et al Ann. Phys.
Meissner, U.-G, A Lacour, Lacour, A, Lacour, A., Meißner, U.-G., Oller, J A, U-G Meißner, Oller, J. A., J A Oller   +8 more
core   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

The Stability of a Modified Jungck-Mann Hybrid Fixed Point Iteration Procedure

, 2018
In this paper, we prove some stability results for sequences of nonself mappings using a modified Jungck-Mann hybrid iterative procedure in aBanach space by employing a class of generalized contractive-like definition.
Akewe, Hudson
core  

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Modified Fast Inertial‐Type Krasnosel’skii‐Mann Iterative Scheme Involving Asymptotically Nonexpansive Mapping

Computational and Mathematical Methods
It is our aim to propose a new iterative algorithm with an inertial term involving asymptotically nonexpansive mapping in the framework of Hilbert spaces. Let T : H ⟶ H be asymptotically nonexpansive mapping with
Emmanuel Akaligwo, Micah Osilike, Noemí DeCastro-García, Angel Luis Muñoz Castañeda, David Escudero García   +4 more
openaire   +1 more source

A modified Mann iterative scheme based on the generalized explicit methods for quasi-nonexpansive mappings in Banach spaces

Advances in the Theory of Nonlinear Analysis and its Application, 2019
In this paper,  we  introduce and study a new iterative algorithm which is a combination of a modified Mann iterative scheme and a generalized    explicit methods (GEM) for finding  a common  fixed points of an infinite family of  quasi-nonexpansive mappings in Banach spaces.
openaire   +3 more sources

Towards Real‐Time Monitoring of Soft Robotic Systems in Endoscopic Application With Ultra‐Flexible Organic Transistor‐Based Strain Sensors

Advanced Electronic Materials, EarlyView.
The integration of ultra‐flexible, all‐organic, field‐effect transistor‐based strain sensors to soft structures is reported for the development of sensorized soft robots. The envisaged application is the development of next‐generation, controllable, and observable soft robotic catheters for endoscopic applications, such as drug delivery. Mechanical and
Usama Mahmood, Andrea Bartolucci, Giulia Casula, Antonello Mascia, Lorenzo Vannozzi, Stefano Lai   +5 more
wiley   +1 more source

Jungck Modified Sp-Iterativescheme

, 2015
In this paper, we introduce Jungck-modified SP-iteration and we study its rate convergence with respect to the rate convergence Jungck-Mann, Jungck-Ishikawa, Jungck-Noor, Jungck-SP, Jungck-CR, Jungck-Karahan, Jungck-Picard S- iterative ...
Abed, Moamar Badree, Jamil, Zeana Zaki
core