A Frequentist Approach Using Weighted Estimating Equations for Survival Analysis of Randomized Controlled Trial With External Control Arm. [PDF]
Sawamoto R, Oba K, Matsuyama Y.
europepmc +1 more source
ON A VARIABLE SELECTION PROCEDURE FOR A MODIFIED LIMITED INFORMATION MAXIMUM LIKELIHOOD METHOD
openaire +1 more source
Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea +53 more
wiley +1 more source
A Two-Step Estimation Approach of Latent Class-Item Response Theory Models in the Presence of DIF and Multidimensionality. [PDF]
Bakk Z, Fabbricatore R.
europepmc +1 more source
Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit +10 more
wiley +1 more source
Caveats on Using Firth's Penalization in the Model-Based Regression Standardization for Rare Diseases. [PDF]
Hashibe S, Hongo W, Shinozaki T.
europepmc +1 more source
The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta +11 more
wiley +1 more source
A python-based automated pipeline for phylogenetic tree construction, visualization, and comparative statistical evaluation. [PDF]
Gambhava B, Patel J, Buch N.
europepmc +1 more source
ABSTRACT Objective Inherited ataxias are clinically diverse neurodegenerative diseases, complicating the choice of outcome measures for trials. In spinocerebellar ataxia (SCA), regulatory concerns about the Scale for the Assessment and Rating of Ataxia (SARA) caused a shift toward functional SARA (f‐SARA), contributing to pivotal trial failure.
Christian Rummey +52 more
wiley +1 more source

