Results 41 to 50 of about 16,734 (266)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Quantum plug n’ play: modular computation in the quantum regime
New Journal of Physics, 2018 Classical computation is modular. It exploits plug n’ play architectures which allow us to use pre-fabricated circuits without knowing their construction.
Jayne Thompson +3 more
doaj +1 more source
Quantum Computation and the Localization of Modular Functors [PDF]
Foundations of Computational Mathematics, 2001 The mathematical problem of localizing modular functors to neighborhoods of points is shown to be closely related to the physical problem of engineering a local Hamiltonian for a computationally universal quantum medium. For genus $=0$ surfaces, such a local Hamiltonian is mathematically defined.
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Computations on Modular Jacobian Surfaces
, 2002 We give a method for finding rational equations of genus 2 curves whose jacobians are abelian varieties $A_f$ attached by Shimura to normalized newforms $f \in S_2( Γ_0(N))$. We present all the curves corresponding to principally polarized surfaces $A_f$ for $N\leq500$.
Enrique González-Jiménez +2 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Computing the modular inverses is as simple as computing the GCDs
Finite Fields and Their Applications, 2008 The authors propose a new algorithm being a variation of the Euclidean Algorithm (EA), used to calculate the greatest common divisors (GCDs) of two integers and inverses for polynomials. They prove some essential features of their new version of EA and show usefulness of their proposal in cryptographic systems.
Chao-Liang Liu +2 more
openaire +2 more sources
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Computer condensation of modular representations
Journal of Symbolic Computation, 1990 This paper contains a general account on the ideas of computer condensation of modular representations, a method to be used in order to construct large matrix representations of finite groups G over fields F with characteristic \(p>0\). (The first condensation programs were written by Parker and Thackray in 1979.) Let V be a finitely generated FG ...
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source