Results 91 to 100 of about 624,167 (298)

A Method for Design of Modular Reconfigurable Machine Tools

Machines, 2017
Presented in this paper is a method for the design of modular reconfigurable machine tools (MRMTs). An MRMT is capable of using a minimal number of modules through reconfiguration to perform the required machining tasks for a family of parts.
Zhengyi Xu, Fengfeng Xi, Lilan Liu, Li Chen   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Methodology for Product Development in Mobile Machinery: Case Example of an Excavator

Machines, 2019
Digital tools have become indispensable for the testing and modification of prototypes in mobile and industrial machine manufacturing. Data that are extracted from virtual experimentation and analysis are both affordable and valuable, due to their ...
Nima Alaei, Emil Kurvinen, Aki Mikkola
doaj   +1 more source

Developing and applying an integrated modular design methodology within a SME [PDF]

, 2007
Modularity within a product can bring advantages to the design process by facilitating enhanced design reuse, reduced lead times, decreased cost and higher levels of quality.
Duffy, A.H.B., Liggat, J., Stewart, B., Tramsheck, R., Wang, W., Whitfield, I., Yan, X.T.   +6 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Comprehensive Decision-Making Approach for Strategic Product Module Planning in Mass Customization

Mathematics
This paper explores the integrated optimization of complex coupled industrial manufacturing systems and production strategies based on user customization needs. Two optimization metrics are considered: one is whether the production process of engineering
Shuo-Fang Liu, Shi-Yu Wang, Hsueh-Hung Tung   +2 more
doaj   +1 more source

Modularization method based on creation of new layout structure

Nihon Kikai Gakkai ronbunshu, 2017
This paper describes a modularization method based on the creation of a new layout structure by combining topology optimization using beam elements and clustering analysis.
Hidekazu NISHIGAKI, Yasuo ASAGA
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Dual arm master controller development [PDF]

, 1985
The advanced servomanipulator (ASM) slave was designed with an anthropomorphic stance gear/torque tube power drives, and modular construction. These features resulted in increased inertia, friction, and backlash relative to tape driven manipulators ...
Kuban, D. P., Perkins, G. S.
core   +1 more source