Results 101 to 110 of about 122,022 (267)

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Design of a Reconfigurable Microfluidic System Enabled by Magnetic Miniature Robots

Advanced Intelligent Systems
Microfluidics permits fluid operations at the microscale. Conventional microfluidic devices have fixed structural configurations, which restrict their adaptability for different applications.
Yuanhe Chen, Zichen Xu, Yu Sun, Qingsong Xu   +3 more
doaj   +1 more source

Innovative Design of a Vertical Retractable Multipurpose Support System

Designs
The Support System with Vertical Retractable Mechanism (SSVRS) is an advancement in telescopic technology that replaces continuous threaded or fluid-dependent interfaces with an internal stepped mechanism based on geometric mechanical interference.
Elkin I. Gutierrez-Velasquez, Hector Parra-Peñuela, Jairo Cortes-Lizarazo   +2 more
doaj   +1 more source

A common modular design of nervous systems originating in soft-bodied invertebrates. [PDF]

Front Physiol, 2023
Gribkova ED, Lee CA, Brown JW, Cui J, Liu Y, Norekian T, Gillette R.   +6 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

An Automated Pipeline for Modular Space Planning Using Generative Design Within a BIM Environment

Applied Sciences
Spatial Allocation Problems (SAP) in multistory buildings present significant challenges, as they require the simultaneous satisfaction of complex geometric constraints and conflicting functional requirements. To address this problem, this study proposes
Wonho Cho, Yeongyu Hwang, WonSeok Choi, Minhyuk Jung, Jaewook Lee   +4 more
doaj   +1 more source

Mirroring Skyrmions in Synthetic Antiferromagnets via Modular Design. [PDF]

Nanomaterials (Basel), 2023
Deng P, Zhuo F, Li H, Cheng Z.
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Freight Railway Train of Modular Type

Механика машин, механизмов и материалов, 2012
This paper gives theoretical substantiation for the effectiveness of replacing the traditional scheme of freight train, representing a chain of cars all successively connected to the locomotive by a modular scheme, where the rolling stock is assembled of
I.K. Alexandrov
doaj