Results 41 to 50 of about 114,053 (266)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Fashion and modular design – Modularity as a design strategy for sustainability
Agathón, 2023 Fashion occupies an essential place in today’s society not only because of the production of garments and their impact at the end of their life but also because of the economic, cultural and social dynamics it determines. Modular design is a valuable strategy for creating complex systems from configurable, separable and adaptable modules that can ...
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Modular Mobile Application Design
Code4Lib Journal, 2012 This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed.
Jim Hahn, Nathaniel Ryckman
doaj
Research on product innovation design of modularization based on theory of TRIZ and axiomatic design
Advances in Mechanical Engineering, 2018 Modular design can shorten the product development cycle and enhance the product research and development capability of enterprises. To better solve the problem of module interface coupling after module partition, the present modular product design ...
Zhong-hang Bai +3 more
doaj +1 more source
Modularity as a strategy for medical design
Agathón, 2023 In the last decade, collaborations between Design and the biomedical field have become increasingly frequent and effective, thanks to their shared focus on user-centred innovation. Design comes into play when unresolved challenges arise, mainly related to the usability of biomedical products, especially in the field of physical and rehabilitative ...
Langella Carla +2 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Research on the Reconfigurable Modular Fixture Design
工程科学与技术, 2010 :How to increase the efficiency and the quality of machine tool fixture design is an important research object of computer-aided technology equipment. The reconfigurable modular fixture design integrated of axiomatic design and design structure matrix ...
Wang Ling, Yin Guofu, Xu Lei
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source