Results 31 to 40 of about 9,578,430 (287)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Conceptual Design and Key Design Considerations for a Relocatable Modular Box-Unit–Space-Grid Gymnasium

Buildings
With the advantages of high construction efficiency and design flexibility, modular buildings are now widely used in school and hotel construction fields.
Chang-Jun Zhong, Bing-Yi Liu, Wan-Jiang Tian, Yun-Han Wang, Hu-Yang Li   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On embeddability of modular robot designs [PDF]

2015 IEEE International Conference on Robotics and Automation (ICRA), 2015
We address the problem of detecting embeddability of modular robots: namely, to decide automatically whether a given modular robot design can simulate the functionality of a seemingly different design. To that end, we introduce a novel graph representation for modular robots and formalize the notion of embedding through topological and kinematic ...
Yannis Mantzouratos, Tarik Tosun, Sanjeev Khanna, Mark Yim   +3 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Long-Term Thermal Stability of Aerogel and Basalt Fiber Pipeline Insulation Under Simulated Atmospheric Aging

Energies
Thermal insulation materials used in power and industrial systems must maintain high performance under extreme environmental conditions. Among such materials, aerogel and basalt fiber are widely applied due to their low thermal conductivity and ease of ...
Irina Akhmetova, Alexander Fedyukhin, Anna Dontsova, Umberto Berardi, Olga Afanaseva, Kamilya Gafiatullina, Maksim Kraikov, Darya Nemova, Valeria Selicati, Roberto Stasi   +9 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Fashion and modular design – Modularity as a design strategy for sustainability

Agathón, 2023
Fashion occupies an essential place in today’s society not only because of the production of garments and their impact at the end of their life but also because of the economic, cultural and social dynamics it determines. Modular design is a valuable strategy for creating complex systems from configurable, separable and adaptable modules that can ...
openaire   +1 more source