Results 61 to 70 of about 9,867,522 (190)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Sustainable Charging Stations for Electric Vehicles

Eng
In this work, we develop a detailed analysis of the current outlook for electric vehicle charging technology, focusing on the various levels and types of charging protocols and connectors used.
Carlos Armenta-Déu, Luis Sancho
doaj   +1 more source

Realising the open virtual commissioning of modular automation systems [PDF]

, 2011
To address the challenges in the automotive industry posed by the need to rapidly manufacture more product variants, and the resultant need for more adaptable production systems, radical changes are now required in the way in which such systems are ...
Jain, Atul, Lee, Leslie J., Robert Harrison (263043), Park, Y., Harrison, Robert, Leslie J. Lee (7204337), Kong, Xiangyu, Bilal Ahmad (773365), Xiangjun Kong (145590), Ahmad, Bilal, Atul Jain (827616), Y. Park (7208792)   +11 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Module Configuration of Rail Freight Transportation with Both Customer Segmentation and Product Family Genealogy in China

Mathematics
The Chinese government is actively restructuring transportation to shift towards more sustainable rail freight transportation (RFT); however, there is still a lack of more systematic optimization in the whole production chain.
Weiya Chen, Shiying Tong, Ziyue Yuan, Xiaoping Fang   +3 more
doaj   +1 more source

Finding Shortest Reconfiguration Sequences for Modular Robots (Media Exposition)

This paper introduces a set of tools built to help researchers design algorithms for modular robots. These tools can brute force solutions to specific reconfigurations, visualize movements of modular robots, and can be used to design specific ...
Clements, Andrew, Downey, Sam, Samanta, Soham, A. Akitaya, Hugo, Stock, Frederick, Eisenbies, Jonathan, Shahrouzi, Gabriel, UML Modular Robotics Group   +7 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Modular Design of Micro/Nanosatellites

, 2011
Труды сотрудников СГАУ(электрон. версия).Methodological guidelines are designed for laboratory work on the course "Modular design of micro / nanosatellites" in the form of calculated and experimental, virtual representation of the data elements of ...
Kramlikh A. V., Samara State Aerospace University   +1 more
core  

Design Solutions For Modular Satellite Architectures [PDF]

, 2010
The cost-effective access to space envisaged by ESA would open a wide range of new opportunities and markets, but is still many years ahead. There is still a lack of devices, circuits, systems which make possible to develop satellites, ground stations ...
SANSOE', Claudio, Leonardo M., Borri, Marco, Reyneri, Leonardo, Claudio Sanso, Claudio Passerone, Maurizio Tranchero, Dante Del, Sansoe, C., Del Corso, Dante, Marco Borri, Stefano Speretta, Tranchero, Maurizio, Speretta, Stefano, Passerone, Claudio   +14 more
core   +1 more source