Results 91 to 100 of about 9,867,522 (190)

Método para auxiliar as escolhas das configurações e de uma arquitetura de enfoque modular para famílias de produtos [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Esta tese é motivada pela crescente necessidade manifestada pelos consumidores por produtos diferenciados e pelo ...
Martini, José Nilton
core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Modular lightweight design - Opportunities and challenges in the digitized development process

, 2019
In this paper the modular lightweight design is introduced as a solution to combine the contrary aspects of modularization and lightweight design. Therefore.
Krause, Dieter, Hanna, Michael, Schwenke, Johann   +2 more
core   +3 more sources

Modular High-Efficiency Bidirectional Isolated DC/DC Converter With Synchronous Control for Energy Storage System

IEEE Open Journal of Power Electronics
This study proposes a modular, high-efficiency bidirectional isolated DC/DC converter with synchronous control. The converter adopts a modular design, where the power of a single module is 500 W.
Yu-En Wu, Po-Chun Liu
doaj   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Model-based systems engineering in modular design

, 2019
Modular design allows to reduce costs based on scaling effects. However, due to strong alternating effects between the resulting modules and products, methods and tools are required that enable engineers to use specific views in which the respective ...
Powelske, Jonas, Birk, Clemens, Albers, Albert, Scherer, Helmut, Muschik, Sabine, Bursac, Nikola   +5 more
core   +1 more source

Innovative Design of a Vertical Retractable Multipurpose Support System

Designs
The Support System with Vertical Retractable Mechanism (SSVRS) is an advancement in telescopic technology that replaces continuous threaded or fluid-dependent interfaces with an internal stepped mechanism based on geometric mechanical interference.
Elkin I. Gutierrez-Velasquez, Hector Parra-Peñuela, Jairo Cortes-Lizarazo   +2 more
doaj   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Freight Railway Train of Modular Type

Механика машин, механизмов и материалов, 2012
This paper gives theoretical substantiation for the effectiveness of replacing the traditional scheme of freight train, representing a chain of cars all successively connected to the locomotive by a modular scheme, where the rolling stock is assembled of
I.K. Alexandrov
doaj