Results 31 to 40 of about 112,898 (267)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Fashion and modular design – Modularity as a design strategy for sustainability

Agathón, 2023
Fashion occupies an essential place in today’s society not only because of the production of garments and their impact at the end of their life but also because of the economic, cultural and social dynamics it determines. Modular design is a valuable strategy for creating complex systems from configurable, separable and adaptable modules that can ...
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Research on the Reconfigurable Modular Fixture Design

工程科学与技术, 2010
:How to increase the efficiency and the quality of machine tool fixture design is an important research object of computer-aided technology equipment. The reconfigurable modular fixture design integrated of axiomatic design and design structure matrix ...
Wang Ling, Yin Guofu, Xu Lei
doaj  

Research on product innovation design of modularization based on theory of TRIZ and axiomatic design

Advances in Mechanical Engineering, 2018
Modular design can shorten the product development cycle and enhance the product research and development capability of enterprises. To better solve the problem of module interface coupling after module partition, the present modular product design ...
Zhong-hang Bai, Shan Zhang, Man Ding, Jian-guang Sun   +3 more
doaj   +1 more source

Modularity as a strategy for medical design

Agathón, 2023
In the last decade, collaborations between Design and the biomedical field have become increasingly frequent and effective, thanks to their shared focus on user-centred innovation. Design comes into play when unresolved challenges arise, mainly related to the usability of biomedical products, especially in the field of physical and rehabilitative ...
Langella Carla, Salvatore Carleo, Marianna De Luca   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modular Mobile Application Design

Code4Lib Journal, 2012
This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed.
Jim Hahn, Nathaniel Ryckman
doaj  

On embeddability of modular robot designs [PDF]

2015 IEEE International Conference on Robotics and Automation (ICRA), 2015
We address the problem of detecting embeddability of modular robots: namely, to decide automatically whether a given modular robot design can simulate the functionality of a seemingly different design. To that end, we introduce a novel graph representation for modular robots and formalize the notion of embedding through topological and kinematic ...
Yannis Mantzouratos, Tarik Tosun, Sanjeev Khanna, Mark Yim   +3 more
openaire   +1 more source