Results 111 to 120 of about 10,207,502 (288)

Model-based systems engineering in modular design

, 2019
Modular design allows to reduce costs based on scaling effects. However, due to strong alternating effects between the resulting modules and products, methods and tools are required that enable engineers to use specific views in which the respective ...
Powelske, Jonas, Birk, Clemens, Albers, Albert, Scherer, Helmut, Muschik, Sabine, Bursac, Nikola   +5 more
core   +1 more source

Modular design of curved beam-based recyclable architected materials. [PDF]

Heliyon, 2023
Yao H, Zhao X, Mi S.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Research on Green Modular Disaster Prevention Product Design and Spatial Configuration Strategy Based on AHP-GIS

Designs
Facing persistent natural catastrophes, the necessity for disaster prevention products in afflicted cities becomes paramount. Modular design has proven to be a viable method for streamlining transportation and manufacturing processes for disaster ...
Xinyi Wang, Yangyang Pan, Yu Liu
doaj   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Research on Modular Space Design of Emergency Hospitals Based on BIM Technology Innovation

Buildings
In recent years, due to the COVID-19 pandemic and the impact of various natural disasters worldwide, the construction of emergency buildings, particularly emergency hospitals, has gained critical importance. This study explores methods for expediting the
Guangping Zhang, Jialei Sun
doaj   +1 more source

A common modular design of nervous systems originating in soft-bodied invertebrates. [PDF]

Front Physiol, 2023
Gribkova ED, Lee CA, Brown JW, Cui J, Liu Y, Norekian T, Gillette R.   +6 more
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Design of a Reconfigurable Microfluidic System Enabled by Magnetic Miniature Robots

Advanced Intelligent Systems
Microfluidics permits fluid operations at the microscale. Conventional microfluidic devices have fixed structural configurations, which restrict their adaptability for different applications.
Yuanhe Chen, Zichen Xu, Yu Sun, Qingsong Xu   +3 more
doaj   +1 more source

Mirroring Skyrmions in Synthetic Antiferromagnets via Modular Design. [PDF]

Nanomaterials (Basel), 2023
Deng P, Zhuo F, Li H, Cheng Z.
europepmc   +1 more source