Results 81 to 90 of about 10,207,502 (288)

The impact of modular product design on innovation compared with design from first principles

, 2010
The research looks at whether modular design methods can compromise innovation when compared with design from first principles. The questions that the authors investigated were: to what extent does modular product design restrict innovation in design? Is
Barker, Tom, Kokotovich, V, Barker, T
core  

Environmental performance driven optimization of urban modular housing layout in Singapore

Journal of Asian Architecture and Building Engineering
With the growing size of cities and the need to renew residential areas, architects are calling for more efficient use of already settled areas. This paper presents a performance-driven architectural design (PDAD) workflow for shape generation and ...
Xiaoyu Shen, Xue Ye
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Design Solutions For Modular Satellite Architectures [PDF]

, 2010
The cost-effective access to space envisaged by ESA would open a wide range of new opportunities and markets, but is still many years ahead. There is still a lack of devices, circuits, systems which make possible to develop satellites, ground stations ...
SANSOE', Claudio, Leonardo M., Borri, Marco, Reyneri, Leonardo, Claudio Sanso, Claudio Passerone, Maurizio Tranchero, Dante Del, Sansoe, C., Del Corso, Dante, Marco Borri, Stefano Speretta, Tranchero, Maurizio, Speretta, Stefano, Passerone, Claudio   +14 more
core   +1 more source

A Comprehensive Decision-Making Approach for Strategic Product Module Planning in Mass Customization

Mathematics
This paper explores the integrated optimization of complex coupled industrial manufacturing systems and production strategies based on user customization needs. Two optimization metrics are considered: one is whether the production process of engineering
Shuo-Fang Liu, Shi-Yu Wang, Hsueh-Hung Tung   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

An Automated Pipeline for Modular Space Planning Using Generative Design Within a BIM Environment

Applied Sciences
Spatial Allocation Problems (SAP) in multistory buildings present significant challenges, as they require the simultaneous satisfaction of complex geometric constraints and conflicting functional requirements. To address this problem, this study proposes
Wonho Cho, Yeongyu Hwang, WonSeok Choi, Minhyuk Jung, Jaewook Lee   +4 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

A modular casing while drilling rig for large-diameter horizontal boreholes for underground rescue

Meitian dizhi yu kantan
ObjectiveOperations in a narrow space pose a challenge to rescue in the case of the collapse of mine roadways or tunnels. To address this challenge, this study developed a modular rescue casing while drilling (CwD) rig system for horizontal boreholes ...
Dong FAN, Xiaoyang NI, Shuyuan MU, Zujie ZOU, Guojun WEN, Yingping LI, Feifei LU   +6 more
doaj   +1 more source