Results 61 to 70 of about 616,220 (283)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

On the Quantum Invariant for the Brieskorn Homology Spheres

, 2005
We study an exact asymptotic behavior of the Witten-Reshetikhin-Turaev invariant for the Brieskorn homology spheres $\Sigma(p_1,p_2,p_3)$ by use of properties of the modular form following a method proposed by Lawrence and Zagier. Key observation is that
Abramowitz M., Fintushel R., Freed D. S., Hikami K., KAZUHIRO HIKAMI, Lang S., Mordell L. J., Rademacher H., Walker K.   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Two approaches to the holomorphic modular bootstrap

Journal of High Energy Physics
The holomorphic bootstrap attempts to classify rational conformal field theories. The straight ahead approach is hard to implement when the number of characters become large.
Suresh Govindarajan, Jagannath Santara
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Modular Robotic Design and Reconfiguring Path Planning

Applied Sciences, 2022
The modular robot is becoming a prevalent research object in robots because of its unique configuration advantages and performance characteristics. It is possible to form robot configurations with different functions by reconfiguring functional modules ...
Ye Dai, Chao-Fang Xiang, Zhao-Xu Liu, Zhao-Long Li, Wen-Yin Qu, Qi-Hao Zhang   +5 more
doaj   +1 more source

Variation of Iwasawa invariants in Hida families

, 2004
Let r : G_Q -> GL_2(Fpbar) be a p-ordinary and p-distinguished irreducible residual modular Galois representation. We show that the vanishing of the algebraic or analytic Iwasawa mu-invariant of a single modular form lifting r implies the vanishing of ...
Emerton, Matthew, Pollack, Robert, Weston, Tom   +2 more
core   +1 more source

Ordinary representations and modular forms [PDF]

Proceedings of the National Academy of Sciences, 1997
Let \(p\) be a prime, and fix on embedding of \(\overline{\mathbb{Q}}\) into \(\overline{\mathbb{Q}}_p\). Let \(f\) be a new form of weight \(k\geq 2\), level \(N\) and character \(\psi\). Let \(\rho_f: \text{Gal} (\overline{\mathbb{Q}}/ \mathbb{Q})\to \text{GL}_2 (\overline{\mathbb{Q}}_p)\) be a continuous representation attached to \(f\) by Eichler ...
Skinner, C. M., Wiles, A. J.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Generalized Eta Transformation Formulas as the Hecke Modular Relation

Axioms
The transformation formula under the action of a general linear fractional transformation for a generalized Dedekind eta function has been the subject of intensive study since the works of Rademacher, Dieter, Meyer, and Schoenberg et al.
Nianliang Wang, Takako Kuzumaki, Shigeru Kanemitsu   +2 more
doaj   +1 more source