Results 61 to 70 of about 10,724 (253)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Tripled Fixed Points and Tripled Best Proximity Points in Modular Function Spaces

AppliedMath
We establish a modular-space framework for the study of tripled fixed points and tripled best proximity points. Under suitable assumptions on the underlying modular (convexity, the Δ2 property, uniform continuity, and uniform convexity-type properties ...
Aynur Ali, Miroslav Hristov, Atanas Ilchev, Diana Nedelcheva, Boyan Zlatanov   +4 more
doaj   +1 more source

Twisted traces of modular functions on hyperbolic 3-space

Journal of Number Theory
We compute analogues of twisted traces of CM values of harmonic modular functions on hyperbolic $3$-space and show that they are essentially given by Fourier coefficients of the $j$-invariant. From this we deduce that the twisted traces of these harmonic modular functions are integers. Additionally, we compute the twisted traces of Eisenstein series on
S. Herrero, Ö. Imamoḡlu, A.-M. von Pippich, M. Schwagenscheidt   +3 more
openaire   +2 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Existence and uniqueness for double-phase Poisson equations with variable growth

Advances in Nonlinear Analysis
We study a class of nonlinear elliptic problems driven by a double-phase operator with variable exponents, arising in the modeling of heterogeneous materials undergoing phase transitions.
Khamsi Mohamed A., Méndez Osvaldo
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A Complex Structure for Two-Typed Tangent Spaces

Entropy
This study concerns Riemannian manifolds with two types of tangent vectors. Let it be given that there are two subspaces of a tangent space with the property that each tangent vector has a unique decomposition as the sum of a vector in one subspace and a
Jan Naudts
doaj   +1 more source

One-Dimensional Hurwitz Spaces, Modular Curves, and Real Forms of Belyi Meromorphic Functions

International Journal of Mathematics and Mathematical Sciences, 2008
Hurwitz spaces are spaces of pairs (S,f) where S is a Riemann surface and f:S→ℂ^ a meromorphic function. In this work, we study 1-dimensional Hurwitz spaces ℋDp of meromorphic p-fold functions with four branched points, three of them fixed; the ...
Antonio F. Costa, Milagros Izquierdo, Gonzalo Riera   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source