Results 21 to 30 of about 56,507 (201)

The analytic index for a family of Dirac-Ramond operators [PDF]

, 2009
We derive a cohomological formula for the analytic index of the Dirac-Ramond operator and we exhibit its modular properties.Comment: 6 ...
Berry, O. Alvarez, P. Windey
core   +5 more sources

Chern-Simons Quantization of (2+1)-Anti-De Sitter Gravity on a Torus [PDF]

, 1994
Chern-Simons formulation of 2+1 dimensional Einstein gravity with a negative cosmological constant is investigated when the spacetime has the topology $ R\times T^{2}$. The physical phase space is shown to be a direct product of two sub-phase spaces each
Carlip S, Carlip S, Dirac P A M, Fujiwara Y, Kiyoshi Ezawa, Louko J, Mess G, Nelson J E, Nelson J E, Unruh W G, Witten E, Woodhouse N J M   +11 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Cop and robber game and hyperbolicity

, 2014
In this note, we prove that all cop-win graphs G in the game in which the robber and the cop move at different speeds s and s' with s'0, this establishes a new - game-theoretical - characterization of Gromov hyperbolicity.
Chalopin, Jérémie, Chepoi, Victor, Papasoglu, Panos, Pecatte, Timothée   +3 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Strong Coupling Test of S-Duality [PDF]

, 1994
By studying the partition function of $N=4$ topologically twisted supersymmetric Yang-Mills on four-manifolds, we make an exact strong coupling test of the Montonen-Olive strong-weak duality conjecture.
't Hooft, 't Hooft, Atiyah, Atiyah, Baulieu, Bershadsky, Blau, Blau, Candelas, Cardy, Cardy, Cumrun Vafa, Dabholkar, Dabholkar, Dixon, Dixon, Dixon, Dixon, Donaldson, Donaldson, Duff, Duff, Duff, Duff, Duff, Edward Witten, Font, Gauntlett, Girardello, Goddard, Greene, Göttsche, Hirzebruch, Hirzebruch, Hitchin, Hitchin, Husemoller, Kac, Khuri, Khuri, Khuri, Klyachko, Koblitz, Lerche, Mathai, Miyake, Montonen, Mukai, Nakajima, Nakajima, Nakashima, Osborn, Qin, Rey, Schwarz, Serre, Shapere, Strominger, Verlinde, Witten, Witten, Witten, Witten, Yamron, Zagier   +64 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Eisenstein Series and String Thresholds [PDF]

, 1998
We investigate the relevance of Eisenstein series for representing certain $G(Z)$-invariant string theory amplitudes which receive corrections from BPS states only. $G(Z)$ may stand for any of the mapping class, T-duality and U-duality groups $Sl(d,Z)$, $
Peixoto, M. M., Rocha, A. C., Sutherland, S., Veerman, J. J. P.   +3 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source