Results 51 to 60 of about 4,418,730 (279)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A metric approach to limit operators
, 2017 We extend the limit operator machinery of Rabinovich, Roch, and Silbermann from Z^N to (bounded geometry, strongly) discrete metric spaces. We do not assume the presence of any group structure or action on our metric spaces.
Spakula, Jan, Willett, Rufus
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FIXED POINT OF MULTIVALUED CONTRACTIONS IN ORTHOGONAL MODULAR METRIC SPACES [PDF]
Facta Universitatis, Series: Mathematics and Informatics, 2019 In this paper we generalize the notion of O−set and establish some fixedpoint theorems for ⊥ − α − ψ−contraction multifunction in the setting of orthogonalmodular metric spaces. As consequences of these results we deduce some theorems inorthogonal modular metric spaces endowed with a graph and partial order.
Hosseini, Hoda, Gordji, Majid Eshaghi
openaire +2 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Simplified Quantum Walk Model for Predicting Missing Links of Complex Networks
Entropy, 2022 Prediction of missing links is an important part of many applications, such as friends’ recommendations on social media, reduction of economic cost of protein functional modular mining, and implementation of accurate recommendations in the shopping ...
Wen Liang +4 more
doaj +1 more source
A new fixed point theorem in modular metric spaces
International Journal of Analysis and Applications, 2018 Summary: In this article, we first give a new fixed point theorem which is main theorem of our study in modular metric spaces. After that, by using this theorem, we express some interesting results. Moreover, we characterize completeness in modular metric spaces via this theorem.
Ali Mutlu, Kubra Ozkan, Utku Gurdal
openaire +6 more sources
Emergence of spacetime from the algebra of total modular Hamiltonians
Journal of High Energy Physics, 2019 We study the action of the CFT total modular Hamiltonian on the CFT representation of bulk fields with spin. In the vacuum of the CFT the total modular Hamiltonian acts as a bulk Lie derivative, reducing on the RT surface to a boost perpendicular to the ...
Daniel Kabat, Gilad Lifschytz
doaj +1 more source