Results 101 to 110 of about 2,156,631 (347)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Reconstruction of modular data from $SL_2(\mathbb{Z})$ representations

open access: yes, 2022
Modular data is the most significant invariant of a modular tensor category. We pursue an approach to the classification of modular data of modular tensor categories by building the modular $S$ and $T$ matrices directly from irreducible representations ...
Siu-Hung Ng   +10 more
core   +1 more source

Vector-valued modular forms and modular tensor categories

open access: yes, 2017
In my talk i'll explain how to find vector-valued modular forms whose multiplier is the modular data of a modular tensor category, and how that can help us reconstruct a rational vertex operator algebra from that category.Non UBCUnreviewedAuthor ...
Gannon, Terry
core   +1 more source

Fermion hierarchies in SU(5) grand unification from Γ 6 ′ $$ {\Gamma}_6^{\prime } $$ modular flavor symmetry

open access: yesJournal of High Energy Physics, 2023
We construct an SU(5) grand unified model in which the hierarchies of the quark and lepton masses and mixing are explained by the Γ 6 ′ $$ {\Gamma}_6^{\prime } $$ modular flavor symmetry.
Yoshihiko Abe   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Systematic Analysis of Speech Transcription Modeling for Reliable Assessment of Depression Severity

open access: yesSakarya University Journal of Computer and Information Sciences
For depression severity assessment, we systematically analyze a modular deep learning pipeline that uses speech transcriptions as input for depression severity prediction.
Hamdi Dibeklioğlu   +1 more
doaj   +1 more source

On modular representations of p-solvable groups

open access: yes, 1977
In this paper we present a module-theoretic proof of Fong’s theory [4] of modular representations of finite p-solvable groups. We show that Fong’s correspondences hold for indecomposable representations, as well as for irreducible ones, and that vertices
G. Cliff
semanticscholar   +1 more source

Modular representations and branching rules for wreath Hecke algebras [PDF]

open access: yes, 2008
We introduce a generalization of degenerate affine Hecke algebra, called wreath Hecke algebra, associated to an arbitrary finite group G. The simple modules of the wreath Hecke algebra and of its associated cyclotomic algebras are classified over an ...
Jin-Kui Wan, Wei-Qiang Wang
semanticscholar   +1 more source

Realization of modular Galois representations in the Jacobians of modular curves

open access: yesThe Ramanujan Journal, 2022
In this paper, we propose an improved algorithm for computing mod $\ell$ Galois representations associated to eigenforms of arbitrary levels prime to $\ell$. Precisely, we present a method to find the Jacobians of modular curves which have the smallest possible dimensions in a well-defined sense to realize the modular Galois representations.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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