Results 41 to 50 of about 166,274 (327)

Modular representations of profinite groups

Journal of Pure and Applied Algebra, 2011
19 ...
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Exploring type-I seesaw under S 3 modular symmetry [PDF]

EPJ Web of Conferences
This work’s novelty lies in using the simplest group i.e. Γ(2) ≃ S 3 modular symmetry implemented on the canonical seesaw to explain neutrino phenomenology.
Behera Mitesh Kumar, Ittisamai Pawin, Pongkitivanichkul Chakrit, Uttayarat Patipan   +3 more
doaj   +1 more source

Modular representations of metabelian groups [PDF]

Transactions of the American Mathematical Society, 1972
The irreducible modular representations, the blocks, and the defect groups of finite metabelian groups are determined. Also the dimensions of the principal indecomposable modules are computed.
openaire   +2 more sources

Blocks of modular representations

Mathematische Zeitschrift, 1962
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Quark masses and CKM hierarchies from $$S_4'$$ S 4 ′ modular flavor symmetry

European Physical Journal C: Particles and Fields, 2023
We propose models to explain the hierarchies of the quark masses and mixing by utilizing the $$S_4^\prime $$ S 4 ′ modular flavor symmetry. The hierarchy is realized by the modulus $$\tau $$ τ stabilized at $$\textrm{Im}\,\tau \gg 1$$ Im τ ≫ 1 , where ...
Yoshihiko Abe, Tetsutaro Higaki, Junichiro Kawamura, Tatsuo Kobayashi   +3 more
doaj   +1 more source

Self-Supervised Learning of Representations for Space Generates Multi-Modular Grid Cells [PDF]

, 2023
Rylan Schaeffer, Mikail Khona, Tzuhsuan Ma, Cristóbal Eyzaguirre, Sanmi Koyejo, Ila Fiete   +5 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source