Results 41 to 50 of about 3,995,756 (285)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Selection of 110 kV Prefabricated Steel Substations Considering Seismic Vulnerability in China

Buildings
Prefabricated modular substations are expected to become the mainstream construction type for substations in China. However, there is a lack of scientific basis for structural selection and seismic performance evaluation. Taking a 110 kV substation as an
Weixian Che, Junbo Liang, Jun Deng, Jiang Yi   +3 more
doaj   +1 more source

Numerical Assessment of The Robustness of a Corner‐supported Modular Steel Building

ce/papers, 2023
Abstract This paper investigates the robustness of a 6‐storey corner‐supported Modular Steel Building (MSB) under notional ground floor corner column removal (i.e. alternate path method). The robustness assessment investigates the following structural effects that were frequently ignored for the sake of simplicity in existing ...
Si Hwa Heng, David Hyland, Michael Hough, Daniel McCrum   +3 more
openaire   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Recommendation of Knockdown Building Design at Yogyakarta Sand Dunes (Restricted and Heritage Areas)

Semesta Teknika, 2019
Sand dunes located in Special Region of Yogyakarta Indonesia is a restricted caused by the heritage and there only four spread in hemisphere one of them in Yogyakara, Indonesia.
Adwitya Bhaskara, Fitri Nugraheni, N. Faried Hanafi   +2 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Case Study in Modular Lightweight Steel Frame Construction: Thermal Bridges and Energy Performance Assessment

Applied Sciences, 2022
This paper proposes an improvement of the conventional Lightweight Steel Frame (LSF) wall structure suitable for the design of high-performance modular buildings. A mobile module, named MUZA, is used as a case study building to analyse the performance of
Bojan Milovanović, Marina Bagarić, Mergim Gaši, Nikolina Vezilić Strmo   +3 more
doaj   +1 more source

Full scale experiments of a steel portal frame building [PDF]

, 1998
While numerous full scale experimental programs have been\ud conducted around the world over the past 50 years to\ud investigate the behaviour of steel portal frame buildings, none\ud have comprehensively investigated the behaviour of such\ud buildings ...
Heldt, T.J., Mahendran, M.
core  

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Contemporary Strategies for the Structural Design of Multi-Story Modular Timber Buildings: A Comprehensive Review

Applied Sciences
Modular timber construction embodies a pioneering and eco-friendly methodology within the building sector. With the notable progress made in manufacturing technologies and the advent of engineered wood products, timber has evolved into a promising ...
Marina Tenório, Rui Ferreira, Victor Belafonte, Filipe Sousa, Cláudio Meireis, Mafalda Fontes, Inês Vale, André Gomes, Rita Alves, Sandra M. Silva, Dinis Leitão, André Fontes, Carlos Maia, Aires Camões, Jorge M. Branco   +14 more
doaj   +1 more source